Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease
Oxidative stress may play a role in the development of atherosclerosis. The purpose of the present study was to explore the relationship between 8-isoprostaglandin F 2α (8- iso-PGF 2α) levels and the presence of coronary artery disease (CAD) and to also clarify whether 8- iso-PGF 2α might add indepe...
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| Veröffentlicht in: | Atherosclerosis 2006-02, Vol.184 (2), p.425-430 |
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| creator | Wang, Bin Pan, Jinshun Wang, Liansheng Zhu, Huaijun Yu, Rongbin Zou, Ying |
| description | Oxidative stress may play a role in the development of atherosclerosis. The purpose of the present study was to explore the relationship between 8-isoprostaglandin F
2α (8-
iso-PGF
2α) levels and the presence of coronary artery disease (CAD) and to also clarify whether 8-
iso-PGF
2α might add independently to measures of CAD extent. The study group consisted of 241 consecutive patients who were undergoing coronary angiography for suspected CAD. 8-
iso-PGF
2α levels were recorded for all participants. The analysis revealed a significant difference in 8-
iso-PGF
2α levels in patients with and without hypertension (
P
<
0.001), in patients with diabetes relative to nondiabetic patients (
P
<
0.05), and in males respect to females (
P
<
0.001). A significant positive correlation was found between age and 8-
iso-PGF
2α levels (
P
<
0.001). 8-
iso-PGF
2α levels correlated with the number of cardiovascular risk factors (
P
<
0.001). 8-
iso-PGF
2α levels were higher in the CAD(+) respect to the CAD(−) groups (337.7
±
80.2 and 263.8
±
74.2
pg/ml and
P
<
0.001). A stepwise elevation in the 8-
iso-PGF
2α levels was found depending on the number of affected vessels (
P
<
0.001). The 8-
iso-PGF
2α levels showed a significant positive correlation with the numbers of >50 and >25% stenotic segments (
P
<
0.001) and the extent score of coronary stenosis (
P
<
0.001). The multivariate logistic regression analysis indicated 8-
iso-PGF
2α as an independent factor associated with CAD (odds ratio, 2.47 and
P
=
0.001). The results suggested that 8-
iso-PGF
2α is associated with the presence of CAD in patients undergoing coronary angiography and is also related to the extent of coronary stenosis in Chinese population. |
| doi_str_mv | 10.1016/j.atherosclerosis.2005.05.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67610179</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0021915005003436</els_id><sourcerecordid>67610179</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-d9b5e05956dec86e0d056663c72ef333d9bba7ce3be9383603ae32227c3c499d3</originalsourceid><addsrcrecordid>eNqNUcFq3DAQFaWl2Sb9haJLevN2ZNmSdeghhCQtBHppzkIrj4kWr-1qtGn7A_3uSKxJoafCoAHNm5k37zF2KWArQKhP-61Ljxhn8mN5A21rgHZbArpXbCM6bSrRdM1rtgGoRWVEC2fsHdEeABoturfsTLTGKKXFhv25Ipp9cCnME_F54Mvo6OB4VwWal7wguQn5iE84Ev8Z0iPP2_kSkXDyyN3Uc_yVcEql189xnlz8zSn_FG48THzJs3N97X6BuJgwpz4QOsIL9mZwI-H7NZ-zh9ub79dfqvtvd1-vr-4r3widqt7sWoTWtKpH3ymEHlqllPS6xkFKmes7pz3KHRrZSQXSoazrWnvpG2N6ec4-nubm034ckZI9BPI4jvnK-UhWaZVV1iYDP5-APmtAEQe7xHDIxK0AW4ywe_uPEbYYYUtAl_s_rIuOuwP2f7tX5TPgcgU48m4copt8nvGC0w00LRQidydcNgCfAkZLPhTt-xDRJ9vP4T8pPQPbmrRn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67610179</pqid></control><display><type>article</type><title>Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Wang, Bin ; Pan, Jinshun ; Wang, Liansheng ; Zhu, Huaijun ; Yu, Rongbin ; Zou, Ying</creator><creatorcontrib>Wang, Bin ; Pan, Jinshun ; Wang, Liansheng ; Zhu, Huaijun ; Yu, Rongbin ; Zou, Ying</creatorcontrib><description><![CDATA[Oxidative stress may play a role in the development of atherosclerosis. The purpose of the present study was to explore the relationship between 8-isoprostaglandin F
2α (8-
iso-PGF
2α) levels and the presence of coronary artery disease (CAD) and to also clarify whether 8-
iso-PGF
2α might add independently to measures of CAD extent. The study group consisted of 241 consecutive patients who were undergoing coronary angiography for suspected CAD. 8-
iso-PGF
2α levels were recorded for all participants. The analysis revealed a significant difference in 8-
iso-PGF
2α levels in patients with and without hypertension (
P
<
0.001), in patients with diabetes relative to nondiabetic patients (
P
<
0.05), and in males respect to females (
P
<
0.001). A significant positive correlation was found between age and 8-
iso-PGF
2α levels (
P
<
0.001). 8-
iso-PGF
2α levels correlated with the number of cardiovascular risk factors (
P
<
0.001). 8-
iso-PGF
2α levels were higher in the CAD(+) respect to the CAD(−) groups (337.7
±
80.2 and 263.8
±
74.2
pg/ml and
P
<
0.001). A stepwise elevation in the 8-
iso-PGF
2α levels was found depending on the number of affected vessels (
P
<
0.001). The 8-
iso-PGF
2α levels showed a significant positive correlation with the numbers of >50 and >25% stenotic segments (
P
<
0.001) and the extent score of coronary stenosis (
P
<
0.001). The multivariate logistic regression analysis indicated 8-
iso-PGF
2α as an independent factor associated with CAD (odds ratio, 2.47 and
P
=
0.001). The results suggested that 8-
iso-PGF
2α is associated with the presence of CAD in patients undergoing coronary angiography and is also related to the extent of coronary stenosis in Chinese population.]]></description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2005.05.008</identifier><identifier>PMID: 15996671</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>8-Isoprostane ; Aged ; Angiography ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; C-Reactive Protein - metabolism ; Cardiology. Vascular system ; China - epidemiology ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Coronary Angiography ; Coronary artery disease ; Coronary heart disease ; Coronary Stenosis - blood ; Coronary Stenosis - diagnostic imaging ; Coronary Stenosis - epidemiology ; Dinoprost - analogs & derivatives ; Dinoprost - blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Heart ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Odds Ratio ; Oxidative Stress ; Risk Factors ; Severity of Illness Index ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Triglycerides - blood</subject><ispartof>Atherosclerosis, 2006-02, Vol.184 (2), p.425-430</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-d9b5e05956dec86e0d056663c72ef333d9bba7ce3be9383603ae32227c3c499d3</citedby><cites>FETCH-LOGICAL-c417t-d9b5e05956dec86e0d056663c72ef333d9bba7ce3be9383603ae32227c3c499d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021915005003436$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17404509$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15996671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Bin</creatorcontrib><creatorcontrib>Pan, Jinshun</creatorcontrib><creatorcontrib>Wang, Liansheng</creatorcontrib><creatorcontrib>Zhu, Huaijun</creatorcontrib><creatorcontrib>Yu, Rongbin</creatorcontrib><creatorcontrib>Zou, Ying</creatorcontrib><title>Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description><![CDATA[Oxidative stress may play a role in the development of atherosclerosis. The purpose of the present study was to explore the relationship between 8-isoprostaglandin F
2α (8-
iso-PGF
2α) levels and the presence of coronary artery disease (CAD) and to also clarify whether 8-
iso-PGF
2α might add independently to measures of CAD extent. The study group consisted of 241 consecutive patients who were undergoing coronary angiography for suspected CAD. 8-
iso-PGF
2α levels were recorded for all participants. The analysis revealed a significant difference in 8-
iso-PGF
2α levels in patients with and without hypertension (
P
<
0.001), in patients with diabetes relative to nondiabetic patients (
P
<
0.05), and in males respect to females (
P
<
0.001). A significant positive correlation was found between age and 8-
iso-PGF
2α levels (
P
<
0.001). 8-
iso-PGF
2α levels correlated with the number of cardiovascular risk factors (
P
<
0.001). 8-
iso-PGF
2α levels were higher in the CAD(+) respect to the CAD(−) groups (337.7
±
80.2 and 263.8
±
74.2
pg/ml and
P
<
0.001). A stepwise elevation in the 8-
iso-PGF
2α levels was found depending on the number of affected vessels (
P
<
0.001). The 8-
iso-PGF
2α levels showed a significant positive correlation with the numbers of >50 and >25% stenotic segments (
P
<
0.001) and the extent score of coronary stenosis (
P
<
0.001). The multivariate logistic regression analysis indicated 8-
iso-PGF
2α as an independent factor associated with CAD (odds ratio, 2.47 and
P
=
0.001). The results suggested that 8-
iso-PGF
2α is associated with the presence of CAD in patients undergoing coronary angiography and is also related to the extent of coronary stenosis in Chinese population.]]></description><subject>8-Isoprostane</subject><subject>Aged</subject><subject>Angiography</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>China - epidemiology</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Coronary Angiography</subject><subject>Coronary artery disease</subject><subject>Coronary heart disease</subject><subject>Coronary Stenosis - blood</subject><subject>Coronary Stenosis - diagnostic imaging</subject><subject>Coronary Stenosis - epidemiology</subject><subject>Dinoprost - analogs & derivatives</subject><subject>Dinoprost - blood</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Oxidative Stress</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Triglycerides - blood</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUcFq3DAQFaWl2Sb9haJLevN2ZNmSdeghhCQtBHppzkIrj4kWr-1qtGn7A_3uSKxJoafCoAHNm5k37zF2KWArQKhP-61Ljxhn8mN5A21rgHZbArpXbCM6bSrRdM1rtgGoRWVEC2fsHdEeABoturfsTLTGKKXFhv25Ipp9cCnME_F54Mvo6OB4VwWal7wguQn5iE84Ev8Z0iPP2_kSkXDyyN3Uc_yVcEql189xnlz8zSn_FG48THzJs3N97X6BuJgwpz4QOsIL9mZwI-H7NZ-zh9ub79dfqvtvd1-vr-4r3widqt7sWoTWtKpH3ymEHlqllPS6xkFKmes7pz3KHRrZSQXSoazrWnvpG2N6ec4-nubm034ckZI9BPI4jvnK-UhWaZVV1iYDP5-APmtAEQe7xHDIxK0AW4ywe_uPEbYYYUtAl_s_rIuOuwP2f7tX5TPgcgU48m4copt8nvGC0w00LRQidydcNgCfAkZLPhTt-xDRJ9vP4T8pPQPbmrRn</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Wang, Bin</creator><creator>Pan, Jinshun</creator><creator>Wang, Liansheng</creator><creator>Zhu, Huaijun</creator><creator>Yu, Rongbin</creator><creator>Zou, Ying</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease</title><author>Wang, Bin ; Pan, Jinshun ; Wang, Liansheng ; Zhu, Huaijun ; Yu, Rongbin ; Zou, Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-d9b5e05956dec86e0d056663c72ef333d9bba7ce3be9383603ae32227c3c499d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>8-Isoprostane</topic><topic>Aged</topic><topic>Angiography</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood and lymphatic vessels</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>China - epidemiology</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Coronary Angiography</topic><topic>Coronary artery disease</topic><topic>Coronary heart disease</topic><topic>Coronary Stenosis - blood</topic><topic>Coronary Stenosis - diagnostic imaging</topic><topic>Coronary Stenosis - epidemiology</topic><topic>Dinoprost - analogs & derivatives</topic><topic>Dinoprost - blood</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Oxidative Stress</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Bin</creatorcontrib><creatorcontrib>Pan, Jinshun</creatorcontrib><creatorcontrib>Wang, Liansheng</creatorcontrib><creatorcontrib>Zhu, Huaijun</creatorcontrib><creatorcontrib>Yu, Rongbin</creatorcontrib><creatorcontrib>Zou, Ying</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Bin</au><au>Pan, Jinshun</au><au>Wang, Liansheng</au><au>Zhu, Huaijun</au><au>Yu, Rongbin</au><au>Zou, Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>184</volume><issue>2</issue><spage>425</spage><epage>430</epage><pages>425-430</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract><![CDATA[Oxidative stress may play a role in the development of atherosclerosis. The purpose of the present study was to explore the relationship between 8-isoprostaglandin F
2α (8-
iso-PGF
2α) levels and the presence of coronary artery disease (CAD) and to also clarify whether 8-
iso-PGF
2α might add independently to measures of CAD extent. The study group consisted of 241 consecutive patients who were undergoing coronary angiography for suspected CAD. 8-
iso-PGF
2α levels were recorded for all participants. The analysis revealed a significant difference in 8-
iso-PGF
2α levels in patients with and without hypertension (
P
<
0.001), in patients with diabetes relative to nondiabetic patients (
P
<
0.05), and in males respect to females (
P
<
0.001). A significant positive correlation was found between age and 8-
iso-PGF
2α levels (
P
<
0.001). 8-
iso-PGF
2α levels correlated with the number of cardiovascular risk factors (
P
<
0.001). 8-
iso-PGF
2α levels were higher in the CAD(+) respect to the CAD(−) groups (337.7
±
80.2 and 263.8
±
74.2
pg/ml and
P
<
0.001). A stepwise elevation in the 8-
iso-PGF
2α levels was found depending on the number of affected vessels (
P
<
0.001). The 8-
iso-PGF
2α levels showed a significant positive correlation with the numbers of >50 and >25% stenotic segments (
P
<
0.001) and the extent score of coronary stenosis (
P
<
0.001). The multivariate logistic regression analysis indicated 8-
iso-PGF
2α as an independent factor associated with CAD (odds ratio, 2.47 and
P
=
0.001). The results suggested that 8-
iso-PGF
2α is associated with the presence of CAD in patients undergoing coronary angiography and is also related to the extent of coronary stenosis in Chinese population.]]></abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>15996671</pmid><doi>10.1016/j.atherosclerosis.2005.05.008</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9150 |
| ispartof | Atherosclerosis, 2006-02, Vol.184 (2), p.425-430 |
| issn | 0021-9150 1879-1484 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67610179 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 8-Isoprostane Aged Angiography Atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels C-Reactive Protein - metabolism Cardiology. Vascular system China - epidemiology Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Coronary Angiography Coronary artery disease Coronary heart disease Coronary Stenosis - blood Coronary Stenosis - diagnostic imaging Coronary Stenosis - epidemiology Dinoprost - analogs & derivatives Dinoprost - blood Enzyme-Linked Immunosorbent Assay Female Heart Humans Incidence Male Medical sciences Middle Aged Odds Ratio Oxidative Stress Risk Factors Severity of Illness Index Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Triglycerides - blood |
| title | Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease |
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