Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease

Oxidative stress may play a role in the development of atherosclerosis. The purpose of the present study was to explore the relationship between 8-isoprostaglandin F 2α (8- iso-PGF 2α) levels and the presence of coronary artery disease (CAD) and to also clarify whether 8- iso-PGF 2α might add independently to measures of CAD extent. The study group consisted of 241 consecutive patients who were undergoing coronary angiography for suspected CAD. 8- iso-PGF 2α levels were recorded for all participants. The analysis revealed a significant difference in 8- iso-PGF 2α levels in patients with and without hypertension ( P < 0.001), in patients with diabetes relative to nondiabetic patients ( P < 0.05), and in males respect to females ( P < 0.001). A significant positive correlation was found between age and 8- iso-PGF 2α levels ( P < 0.001). 8- iso-PGF 2α levels correlated with the number of cardiovascular risk factors ( P < 0.001). 8- iso-PGF 2α levels were higher in the CAD(+) respect to the CAD(−) groups (337.7 ± 80.2 and 263.8 ± 74.2 pg/ml and P < 0.001). A stepwise elevation in the 8- iso-PGF 2α levels was found depending on the number of affected vessels ( P < 0.001). The 8- iso-PGF 2α levels showed a significant positive correlation with the numbers of >50 and >25% stenotic segments ( P < 0.001) and the extent score of coronary stenosis ( P < 0.001). The multivariate logistic regression analysis indicated 8- iso-PGF 2α as an independent factor associated with CAD (odds ratio, 2.47 and P = 0.001). The results suggested that 8- iso-PGF 2α is associated with the presence of CAD in patients undergoing coronary angiography and is also related to the extent of coronary stenosis in Chinese population.