The mitochondria and insulin release: Nnt just a passing relationship
Nicotinamide nucleotide transhydrogenase (Nnt) detoxifies reactive oxygen species (ROS), byproducts of mitochondrial metabolism that, when accumulated, can decrease mitochondrial ATP production. In this issue of Cell Metabolism, Freeman et al. (2006) demonstrate that Nnt in pancreatic β cells is imp...
Gespeichert in:
| Veröffentlicht in: | Cell metabolism 2006-01, Vol.3 (1), p.5-7 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7 |
|---|---|
| container_issue | 1 |
| container_start_page | 5 |
| container_title | Cell metabolism |
| container_volume | 3 |
| creator | Remedi, M.S. Nichols, C.G. Koster, J.C. |
| description | Nicotinamide nucleotide transhydrogenase (Nnt) detoxifies reactive oxygen species (ROS), byproducts of mitochondrial metabolism that, when accumulated, can decrease mitochondrial ATP production. In this issue of Cell Metabolism, Freeman et al. (2006) demonstrate that Nnt in pancreatic β cells is important for insulin release. Their compelling data highlight the critical roles for ATP generation and subsequent closure of KATP channels for insulin secretion. |
| doi_str_mv | 10.1016/j.cmet.2005.12.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67609801</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1550413105003773</els_id><sourcerecordid>67609801</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-231cb36891702e8114bd497e5d4da534c67baf80ef6005e89b66366cf0762fb43</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMo7rr6BzxIT95a89GmjXiRZf2ARS_rOaTp1E1p05q0gv_elF3w5mkG5nlfmAeha4ITggm_axLdwZhQjLOE0ARjdoKWRDAa5ynFp2HPMhynhJEFuvC-CQBngp2jBQlTpEIs0Wa3h6gzY6_3va2cUZGyVWSsn1pjIwctKA_30Zsdo2byY6SiQXlv7Od8U6Pprd-b4RKd1ar1cHWcK_TxtNmtX-Lt-_Pr-nEbayaKMaaM6JLxQpAcUygIScsqFTlkVVqpjKWa56WqCww1Dz9BIUrOGee6xjmndZmyFbo99A6u_5rAj7IzXkPbKgv95CXPORYFJgGkB1C73nsHtRyc6ZT7kQTLWZ5s5CxPzvIkoTK4CaGbY_tUdlD9RY62AvBwACD8-G3ASa8NWA2VcaBHWfXmv_5fkhJ_sQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67609801</pqid></control><display><type>article</type><title>The mitochondria and insulin release: Nnt just a passing relationship</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Remedi, M.S. ; Nichols, C.G. ; Koster, J.C.</creator><creatorcontrib>Remedi, M.S. ; Nichols, C.G. ; Koster, J.C.</creatorcontrib><description>Nicotinamide nucleotide transhydrogenase (Nnt) detoxifies reactive oxygen species (ROS), byproducts of mitochondrial metabolism that, when accumulated, can decrease mitochondrial ATP production. In this issue of Cell Metabolism, Freeman et al. (2006) demonstrate that Nnt in pancreatic β cells is important for insulin release. Their compelling data highlight the critical roles for ATP generation and subsequent closure of KATP channels for insulin secretion.</description><identifier>ISSN: 1550-4131</identifier><identifier>EISSN: 1932-7420</identifier><identifier>DOI: 10.1016/j.cmet.2005.12.003</identifier><identifier>PMID: 16399499</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Insulin - metabolism ; Insulin Secretion ; Insulin-Secreting Cells - enzymology ; Insulin-Secreting Cells - metabolism ; Mice ; Mitochondria - enzymology ; Mitochondrial Proteins - genetics ; Mitochondrial Proteins - physiology ; NADP Transhydrogenases - genetics ; NADP Transhydrogenases - physiology</subject><ispartof>Cell metabolism, 2006-01, Vol.3 (1), p.5-7</ispartof><rights>2006 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-231cb36891702e8114bd497e5d4da534c67baf80ef6005e89b66366cf0762fb43</citedby><cites>FETCH-LOGICAL-c398t-231cb36891702e8114bd497e5d4da534c67baf80ef6005e89b66366cf0762fb43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cmet.2005.12.003$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16399499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Remedi, M.S.</creatorcontrib><creatorcontrib>Nichols, C.G.</creatorcontrib><creatorcontrib>Koster, J.C.</creatorcontrib><title>The mitochondria and insulin release: Nnt just a passing relationship</title><title>Cell metabolism</title><addtitle>Cell Metab</addtitle><description>Nicotinamide nucleotide transhydrogenase (Nnt) detoxifies reactive oxygen species (ROS), byproducts of mitochondrial metabolism that, when accumulated, can decrease mitochondrial ATP production. In this issue of Cell Metabolism, Freeman et al. (2006) demonstrate that Nnt in pancreatic β cells is important for insulin release. Their compelling data highlight the critical roles for ATP generation and subsequent closure of KATP channels for insulin secretion.</description><subject>Animals</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>Insulin-Secreting Cells - enzymology</subject><subject>Insulin-Secreting Cells - metabolism</subject><subject>Mice</subject><subject>Mitochondria - enzymology</subject><subject>Mitochondrial Proteins - genetics</subject><subject>Mitochondrial Proteins - physiology</subject><subject>NADP Transhydrogenases - genetics</subject><subject>NADP Transhydrogenases - physiology</subject><issn>1550-4131</issn><issn>1932-7420</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6BzxIT95a89GmjXiRZf2ARS_rOaTp1E1p05q0gv_elF3w5mkG5nlfmAeha4ITggm_axLdwZhQjLOE0ARjdoKWRDAa5ynFp2HPMhynhJEFuvC-CQBngp2jBQlTpEIs0Wa3h6gzY6_3va2cUZGyVWSsn1pjIwctKA_30Zsdo2byY6SiQXlv7Od8U6Pprd-b4RKd1ar1cHWcK_TxtNmtX-Lt-_Pr-nEbayaKMaaM6JLxQpAcUygIScsqFTlkVVqpjKWa56WqCww1Dz9BIUrOGee6xjmndZmyFbo99A6u_5rAj7IzXkPbKgv95CXPORYFJgGkB1C73nsHtRyc6ZT7kQTLWZ5s5CxPzvIkoTK4CaGbY_tUdlD9RY62AvBwACD8-G3ASa8NWA2VcaBHWfXmv_5fkhJ_sQ</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Remedi, M.S.</creator><creator>Nichols, C.G.</creator><creator>Koster, J.C.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>The mitochondria and insulin release: Nnt just a passing relationship</title><author>Remedi, M.S. ; Nichols, C.G. ; Koster, J.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-231cb36891702e8114bd497e5d4da534c67baf80ef6005e89b66366cf0762fb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Insulin - metabolism</topic><topic>Insulin Secretion</topic><topic>Insulin-Secreting Cells - enzymology</topic><topic>Insulin-Secreting Cells - metabolism</topic><topic>Mice</topic><topic>Mitochondria - enzymology</topic><topic>Mitochondrial Proteins - genetics</topic><topic>Mitochondrial Proteins - physiology</topic><topic>NADP Transhydrogenases - genetics</topic><topic>NADP Transhydrogenases - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Remedi, M.S.</creatorcontrib><creatorcontrib>Nichols, C.G.</creatorcontrib><creatorcontrib>Koster, J.C.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Remedi, M.S.</au><au>Nichols, C.G.</au><au>Koster, J.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The mitochondria and insulin release: Nnt just a passing relationship</atitle><jtitle>Cell metabolism</jtitle><addtitle>Cell Metab</addtitle><date>2006-01</date><risdate>2006</risdate><volume>3</volume><issue>1</issue><spage>5</spage><epage>7</epage><pages>5-7</pages><issn>1550-4131</issn><eissn>1932-7420</eissn><abstract>Nicotinamide nucleotide transhydrogenase (Nnt) detoxifies reactive oxygen species (ROS), byproducts of mitochondrial metabolism that, when accumulated, can decrease mitochondrial ATP production. In this issue of Cell Metabolism, Freeman et al. (2006) demonstrate that Nnt in pancreatic β cells is important for insulin release. Their compelling data highlight the critical roles for ATP generation and subsequent closure of KATP channels for insulin secretion.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16399499</pmid><doi>10.1016/j.cmet.2005.12.003</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1550-4131 |
| ispartof | Cell metabolism, 2006-01, Vol.3 (1), p.5-7 |
| issn | 1550-4131 1932-7420 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67609801 |
| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - enzymology Insulin-Secreting Cells - metabolism Mice Mitochondria - enzymology Mitochondrial Proteins - genetics Mitochondrial Proteins - physiology NADP Transhydrogenases - genetics NADP Transhydrogenases - physiology |
| title | The mitochondria and insulin release: Nnt just a passing relationship |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T18%3A40%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20mitochondria%20and%20insulin%20release:%20Nnt%20just%20a%20passing%20relationship&rft.jtitle=Cell%20metabolism&rft.au=Remedi,%20M.S.&rft.date=2006-01&rft.volume=3&rft.issue=1&rft.spage=5&rft.epage=7&rft.pages=5-7&rft.issn=1550-4131&rft.eissn=1932-7420&rft_id=info:doi/10.1016/j.cmet.2005.12.003&rft_dat=%3Cproquest_cross%3E67609801%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67609801&rft_id=info:pmid/16399499&rft_els_id=S1550413105003773&rfr_iscdi=true |