The mitochondria and insulin release: Nnt just a passing relationship

Nicotinamide nucleotide transhydrogenase (Nnt) detoxifies reactive oxygen species (ROS), byproducts of mitochondrial metabolism that, when accumulated, can decrease mitochondrial ATP production. In this issue of Cell Metabolism, Freeman et al. (2006) demonstrate that Nnt in pancreatic β cells is imp...

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Veröffentlicht in:	Cell metabolism 2006-01, Vol.3 (1), p.5-7
Hauptverfasser:	Remedi, M.S., Nichols, C.G., Koster, J.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - enzymology Insulin-Secreting Cells - metabolism Mice Mitochondria - enzymology Mitochondrial Proteins - genetics Mitochondrial Proteins - physiology NADP Transhydrogenases - genetics NADP Transhydrogenases - physiology
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Zusammenfassung:	Nicotinamide nucleotide transhydrogenase (Nnt) detoxifies reactive oxygen species (ROS), byproducts of mitochondrial metabolism that, when accumulated, can decrease mitochondrial ATP production. In this issue of Cell Metabolism, Freeman et al. (2006) demonstrate that Nnt in pancreatic β cells is important for insulin release. Their compelling data highlight the critical roles for ATP generation and subsequent closure of KATP channels for insulin secretion.
ISSN:	1550-4131 1932-7420
DOI:	10.1016/j.cmet.2005.12.003