Biological and Prognostic Significance of Chromosome 5q Deletions in Myeloid Malignancies

The presence of del(5q), either as the sole karyotypic abnormality or as part of a more complex karyotype, has distinct clinical implications for myelodysplastic syndromes (MDS) and acute myeloid leukemia. The 5q− syndrome, a subtype of low-risk MDS, is characterized by an isolated 5q deletion and

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Veröffentlicht in:	Clinical cancer research 2006-01, Vol.12 (1), p.5-10
Hauptverfasser:	GIAGOUNIDIS, Aristoteles A. N, GERMING, Ulrich, AUL, Carlo
Format:	Artikel
Sprache:	eng
Schlagworte:	5q− syndrome Antineoplastic agents Biological and medical sciences Chromosome aberrations Chromosome Deletion Chromosomes, Human, Pair 5 - genetics Clinical Trials as Topic cytogenetic Female Hematologic and hematopoietic diseases hematopoiesis Hematopoiesis - drug effects Hematopoiesis - genetics Humans immunomodulatory drugs lenalidomide Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical genetics Medical sciences myelodysplastic syndromes Myeloproliferative Disorders - genetics Myeloproliferative Disorders - therapy Pharmacology. Drug treatments Prognosis Thalidomide - analogs & derivatives Thalidomide - therapeutic use
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Zusammenfassung:	The presence of del(5q), either as the sole karyotypic abnormality or as part of a more complex karyotype, has distinct clinical implications for myelodysplastic syndromes (MDS) and acute myeloid leukemia. The 5q− syndrome, a subtype of low-risk MDS, is characterized by an isolated 5q deletion and
ISSN:	1078-0432 1557-3265
DOI:	10.1158/1078-0432.CCR-05-1437