Palladium-Catalyzed Domino Direct Arylation/N-Arylation: Convenient Synthesis of Phenanthridines

Palladium-Catalyzed Domino Direct Arylation/N-Arylation: Convenient Synthesis of Phenanthridines

Domino reactions possess the ability to generate complexity from simple starting materials. Disclosed is a strategy for the domino direct arylation/N‐arylation for the facile construction of diverse phenanthridine derivatives (see scheme; TMS=trimethylsilyl, TBDMS=tert‐butyldimethylsilyl).

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (36), p.6713-6716
Hauptverfasser: Candito, David A, Lautens, Mark
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
CH activation
domino reactions
imines
Molecular Structure
N‐arylation
Organometallic Compounds - chemistry
palladium
Palladium - chemistry
Phenanthridines - chemical synthesis
Phenanthridines - chemistry
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Zusammenfassung:Domino reactions possess the ability to generate complexity from simple starting materials. Disclosed is a strategy for the domino direct arylation/N‐arylation for the facile construction of diverse phenanthridine derivatives (see scheme; TMS=trimethylsilyl, TBDMS=tert‐butyldimethylsilyl).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200902400