The Morita-Baylis-Hillman adducts of beta-aryl nitroethylenes with other activated alkenes: synthesis and anticancer activity studies

The Morita-Baylis-Hillman (MBH) adducts of beta-aryl nitroethylenes with methyl vinyl ketone (MVK) and acrylate, formed in moderate to good yield when mediated by imidazole/LiCl in THF at room temperature, inhibit HeLa cell proliferation by binding to tubulin.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2006-01 (3), p.338-340
Hauptverfasser:	Dadwal, Mamta, Mohan, Renu, Panda, Dulal, Mobin, Shaikh M, Namboothiri, Irishi N N
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates - chemistry Alkenes - chemical synthesis Alkenes - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Binding Sites Butanones - chemistry Cell Proliferation - drug effects Ethylenes - chemistry Ethylenes - pharmacology Furans - chemistry HeLa Cells Humans Imidazoles - chemistry Lithium Chloride - chemistry Models, Chemical Nitro Compounds - chemistry Nitro Compounds - pharmacology Temperature Tubulin - metabolism
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Beschreibung
Zusammenfassung:	The Morita-Baylis-Hillman (MBH) adducts of beta-aryl nitroethylenes with methyl vinyl ketone (MVK) and acrylate, formed in moderate to good yield when mediated by imidazole/LiCl in THF at room temperature, inhibit HeLa cell proliferation by binding to tubulin.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b512267h