Self-Replicating Amphiphilic β-Sheet Peptides

Self-Replicating Amphiphilic β-Sheet Peptides

Simple peptides can do that too: Synthetic amphiphilic peptides 1, formed of electrophilic (E) and nucleophilic (N) precursors, are close analogues of the Glu‐(Phe‐Glu)n molecules. The peptides form soluble one‐dimensional β‐sheet aggregates in water (see picture), and serve to significantly acceler...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (36), p.6683-6686
Hauptverfasser: Rubinov, Boris, Wagner, Nathaniel, Rapaport, Hanna, Ashkenasy, Gonen
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Catalysis
Circular Dichroism
Kinetics
Molecular Sequence Data
Molecular Structure
origins of life
peptides
Peptides - chemistry
Protein Structure, Secondary
self‐replication
systems chemistry
β sheet structures
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Beschreibung
Zusammenfassung:Simple peptides can do that too: Synthetic amphiphilic peptides 1, formed of electrophilic (E) and nucleophilic (N) precursors, are close analogues of the Glu‐(Phe‐Glu)n molecules. The peptides form soluble one‐dimensional β‐sheet aggregates in water (see picture), and serve to significantly accelerate chemical ligation and self‐replication.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200902790