“Click Chemistry” Inspired Synthesis of pseudo-Oligosaccharides and Amino Acid Glycoconjugates

[reaction: see text] Various pseudo-oligosacchardies and amino acid glycoconjugates were synthesized via an intermolecular 1,3-dipolar cycloaddition ("click") reaction using easily accessible carbohydrate and amino acid derived azides and alkynes as building blocks. It is pertinent to ment...

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Veröffentlicht in:Journal of organic chemistry 2006-01, Vol.71 (1), p.364-367
Hauptverfasser: HOTHA, Srinivas, KASHYAP, Sudhir
Format: Artikel
Sprache:eng
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Zusammenfassung:[reaction: see text] Various pseudo-oligosacchardies and amino acid glycoconjugates were synthesized via an intermolecular 1,3-dipolar cycloaddition ("click") reaction using easily accessible carbohydrate and amino acid derived azides and alkynes as building blocks. It is pertinent to mention that the conjugation reaction is highly regioselective and high yielding and can be carried out under mild reaction conditions.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo051731q