Expedited Palladium-Catalyzed Amination of Aryl Nonaflates through the Use of Microwave-Irradiation and Soluble Organic Amine Bases

Microwave-assisted, palladium-catalyzed C−N bond-forming reactions with aryl/heteroaryl nonaflates and amines using the soluble amine bases DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) or MTBD (7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene) and ligands (1 − 3) resulted in good to excellent yields (71−99%...

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Veröffentlicht in:	Journal of organic chemistry 2006-01, Vol.71 (1), p.430-433
Hauptverfasser:	Tundel, Rachel E, Anderson, Kevin W, Buchwald, Stephen L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amination Amines - chemistry Catalysis Chemistry Electrons Exact sciences and technology Imines - chemistry Ligands Microwaves Molecular Structure Noncondensed benzenic compounds Organic chemistry Palladium - chemistry Preparations and properties Solubility
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Microwave-assisted, palladium-catalyzed C−N bond-forming reactions with aryl/heteroaryl nonaflates and amines using the soluble amine bases DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) or MTBD (7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene) and ligands (1 − 3) resulted in good to excellent yields (71−99%) of arylamines in short reaction times (1−45 min).
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo052131u