Treatment of locally advanced non-small cell lung cancer

Approximately one third of non-small cell lung cancer (NSCLC) patients will present with locally advanced, stage III disease. With the use of pretreatment positron emission testing and mediastinal lymph node sampling, classifying stage III NSCLC has become more involved and treatment strategies have...

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Veröffentlicht in:Clinical advances in hematology & oncology 2009-07, Vol.7 (7), p.455-480
Hauptverfasser: Fidler, Mary Jo, Kim, Anthony W, Zusag, Thomas, Bonomi, Philip
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container_title Clinical advances in hematology & oncology
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creator Fidler, Mary Jo
Kim, Anthony W
Zusag, Thomas
Bonomi, Philip
description Approximately one third of non-small cell lung cancer (NSCLC) patients will present with locally advanced, stage III disease. With the use of pretreatment positron emission testing and mediastinal lymph node sampling, classifying stage III NSCLC has become more involved and treatment strategies have shifted from single modality thoracic radiation to combined chemoradiotherapy. This article reviews evidence-based strategies in the treatment of locally advanced NSCLC and presents new efforts for improving the poor prognosis of this disease by incorporating novel chemotherapy and biologic based regimens.
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Non-Small-Cell Lung - drug therapy
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - radiotherapy
Clinical Trials, Phase II as Topic
Clinical Trials, Phase III as Topic
Combined Modality Therapy
Humans
Lung Neoplasms - drug therapy
Lung Neoplasms - pathology
Lung Neoplasms - radiotherapy
Neoplasm Staging
Radiotherapy - methods
title Treatment of locally advanced non-small cell lung cancer
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