Treatment of locally advanced non-small cell lung cancer

Approximately one third of non-small cell lung cancer (NSCLC) patients will present with locally advanced, stage III disease. With the use of pretreatment positron emission testing and mediastinal lymph node sampling, classifying stage III NSCLC has become more involved and treatment strategies have...

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Veröffentlicht in:	Clinical advances in hematology & oncology 2009-07, Vol.7 (7), p.455-480
Hauptverfasser:	Fidler, Mary Jo, Kim, Anthony W, Zusag, Thomas, Bonomi, Philip
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - radiotherapy Clinical Trials, Phase II as Topic Clinical Trials, Phase III as Topic Combined Modality Therapy Humans Lung Neoplasms - drug therapy Lung Neoplasms - pathology Lung Neoplasms - radiotherapy Neoplasm Staging Radiotherapy - methods
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Beschreibung
Zusammenfassung:	Approximately one third of non-small cell lung cancer (NSCLC) patients will present with locally advanced, stage III disease. With the use of pretreatment positron emission testing and mediastinal lymph node sampling, classifying stage III NSCLC has become more involved and treatment strategies have shifted from single modality thoracic radiation to combined chemoradiotherapy. This article reviews evidence-based strategies in the treatment of locally advanced NSCLC and presents new efforts for improving the poor prognosis of this disease by incorporating novel chemotherapy and biologic based regimens.
ISSN:	1543-0790