Amphidinolide B:  Asymmetric Synthesis of a C7−C20 Synthon

An asymmetric synthesis of a C7−C20 synthon of amphidinolide B is described. The synthesis entails the construction of C7−C13 and C14−C20 fragments and makes extensive use of catalytic asymmetric bond constructions to establish the requisite stereochemical relationships. Fragment coupling proceeds by Suzuki cross-coupling and installs the trisubstituted diene unit that is among amphidinolide B's defining structural features.