Indoloprodigiosins from the C-10 bipyrrolic precursor: New antiproliferative prodigiosin analogs

The condensation of the C-10 methoxybipyrrole precursor ( 3) of prodigiosin with indoles and a related pyrrole derivative yields novel analogs of prodigiosin. Biological evaluation of these products revealed compounds that inhibit cancer cell proliferation from 50 nM to 50 μM.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-02, Vol.16 (3), p.701-704
Hauptverfasser:	Baldino, Carmen M., Parr, Jonathan, Wilson, Christopher J., Ng, Shi-Chung, Yohannes, Daniel, Wasserman, Harry H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antiproliferative agent Biological and medical sciences Cell Proliferation - drug effects General aspects Indole Indoles - chemistry Medical sciences Molecular Structure Pharmacology. Drug treatments Prodigiosin Prodigiosin - analogs & derivatives Prodigiosin - chemical synthesis Prodigiosin - pharmacology Pyrrole Pyrroles - chemistry Structure-Activity Relationship Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	The condensation of the C-10 methoxybipyrrole precursor ( 3) of prodigiosin with indoles and a related pyrrole derivative yields novel analogs of prodigiosin. Biological evaluation of these products revealed compounds that inhibit cancer cell proliferation from 50 nM to 50 μM.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2005.10.027