Polymorphism of Methylenetetrahydrofolate Reductase Gene (C677T MTHFR) is Not a Confounding Factor of the Relationship Between Serum Uric Acid Level and the Prevalence of Hypertension in Japanese Men

Background The association between serum uric acid (UA) and the prevalence of hypertension, and the relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphism and hypertension remains unclear. The aim of the present study was to investigate whether the C677T MTHFR mutation genotyp...

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Veröffentlicht in:Circulation Journal 2006, Vol.70(1), pp.83-87
Hauptverfasser: Lwin, Htay, Yokoyama, Tetsuji, Yoshiike, Nobuo, Saito, Kyoko, Yamamoto, Akio, Date, Chigusa, Tanaka, Heizo
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Sprache:eng
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Zusammenfassung:Background The association between serum uric acid (UA) and the prevalence of hypertension, and the relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphism and hypertension remains unclear. The aim of the present study was to investigate whether the C677T MTHFR mutation genotype (VV) is independently associated with the prevalence of hypertension or blood pressure (BP), and examined any interaction of MTHFR and UA with BP. Methods and Results Participants were randomly selected from all residents (aged 40-69 years) in a rural county of Japan, and the data for the men (n=335) were analyzed. `Hypertension' was defined as systolic BP ≥140 and/or diastolic BP ≥90 mmHg and/or being administered antihypertensive medication. Serum UA level was independently associated with the prevalence of hypertension (odds ratio (95% confidence interval) =2.7 (1.2-5.9), p=0.047) for the highest tertile of serum UA (≥398.5 μmol/L (6.7 mg/dl)) vs that of the lowest tertile (
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.70.83