A new antibacterial clerodane diterpenoid from the resinous exudate of Haplopappus uncinatus

The antibacterial activity of Haplopappus uncinatus is attributed to a new clerodane diterpenoid, 18-acetoxy- cis-cleroda-3-en-15-oic acid (10βH, 16ξ 19β, 17β, 20α form) ( 1), isolated as a major component from the resinous exudates of its twigs and leaves, together with the inactive 3,5-dihydroxy-6...

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Veröffentlicht in:	Journal of ethnopharmacology 2006-01, Vol.103 (2), p.297-301
Hauptverfasser:	Urzúa, A., Jara, F., Tojo, E., Wilkens, M., Mendoza, L., Rezende, M.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	18-Acetoxy- cis-cleroda-3-en-15-oic acid (10βH, 16ξ 19β, 17β, 20α form) Anti-Infective Agents - chemistry Anti-Infective Agents - isolation & purification Antibacterial activity Asteraceae Biological and medical sciences Diterpenes - chemistry Diterpenes - isolation & purification General pharmacology Haplopappus Haplopappus uncinatus Medical sciences Microbial Sensitivity Tests Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - isolation & purification Resinous exudates Structure-Activity Relationship
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Zusammenfassung:	The antibacterial activity of Haplopappus uncinatus is attributed to a new clerodane diterpenoid, 18-acetoxy- cis-cleroda-3-en-15-oic acid (10βH, 16ξ 19β, 17β, 20α form) ( 1), isolated as a major component from the resinous exudates of its twigs and leaves, together with the inactive 3,5-dihydroxy-6,7,3′,4′-tetramethoxyflavone, n-alkanes and a few sesquiterpenoids.
ISSN:	0378-8741 1872-7573
DOI:	10.1016/j.jep.2005.09.042