Ordered nanoclusters in lipid-cholesterol membranes

Ordered nanoclusters in lipid-cholesterol membranes

X-ray diffraction of sphingomyelin-dihydrocholesterol (SM-DChol) monolayers revealed short-ranged ( approximately 25 A) 2D ordering. These nanoclusters show two distinct regions: below the cusp point of the phase diagram (35 mol% DChol), a constant d spacing was observed; above the cusp, the d spaci...

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Veröffentlicht in:Physical review letters 2009-07, Vol.103 (2), p.028103-028103, Article 028103
Hauptverfasser: Ratajczak, Maria K, Chi, Eva Y, Frey, Shelli L, Cao, Kathleen D, Luther, Laura M, Lee, Ka Yee C, Majewski, Jaroslaw, Kjaer, Kristian
Format: Artikel
Sprache:eng
Schlagworte:
Cholestanol - chemistry
Membrane Fluidity
Membranes, Artificial
Nanostructures - chemistry
Sphingomyelins - chemistry
X-Ray Diffraction
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Zusammenfassung:X-ray diffraction of sphingomyelin-dihydrocholesterol (SM-DChol) monolayers revealed short-ranged ( approximately 25 A) 2D ordering. These nanoclusters show two distinct regions: below the cusp point of the phase diagram (35 mol% DChol), a constant d spacing was observed; above the cusp, the d spacing increases linearly with DChol in accordance to Vegard's law for binary alloys. The components in this lipidic alloy are thus a 65ratio35 SM-DChol entity and excess DChol. Reflectivity data further support the emergence above the cusp of an uncomplexed DChol population with greater vertical mobility.
ISSN:0031-9007
1079-7114
DOI:10.1103/PhysRevLett.103.028103