Enhanced Early Morning Salivary Cortisol in Neuroticism

Enhanced Early Morning Salivary Cortisol in Neuroticism

OBJECTIVE: Neuroticism is a predisposing factor for major depression. The increase in salivary cortisol that follows waking provides a reliable measure of adrenocortical activity, and this response is increased in recovered depressed patients. This study compared waking cortisol levels in healthy su...

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Veröffentlicht in:The American journal of psychiatry 2005-04, Vol.162 (4), p.807-809
Hauptverfasser: Portella, Maria J., Harmer, Catherine J., Flint, Jonathan, Cowen, Philip, Goodwin, Guy M.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Biomarkers
Body fluids
Circadian Rhythm - physiology
Depressive Disorder, Major - diagnosis
Fundamental and applied biological sciences. Psychology
Hormones
Humans
Hydrocortisone - analysis
Mental depression
Neurotic Disorders - diagnosis
Neurotic Disorders - psychology
Personality - classification
Personality - physiology
Personality Inventory
Personality traits
Personality. Affectivity
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Saliva - chemistry
Wakefulness - physiology
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Zusammenfassung:OBJECTIVE: Neuroticism is a predisposing factor for major depression. The increase in salivary cortisol that follows waking provides a reliable measure of adrenocortical activity, and this response is increased in recovered depressed patients. This study compared waking cortisol levels in healthy subjects with high and low levels of neuroticism without a previous history of depression. METHOD: Salivary cortisol levels were measured upon waking and at 15-minute intervals for the next hour in volunteers selected to have high (>19 23) or low (
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.162.4.807