Bright and Stable Core−Shell Fluorescent Silica Nanoparticles

A class of highly fluorescent and photostable core−shell nanoparticles from a modified Stöber synthesis in the size range of 20−30 nm is described. These nanoparticles are monodisperse in solution, 20 times brighter, and more photostable than their constituent fluorophore, and are amenable to specif...

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Veröffentlicht in:Nano letters 2005-01, Vol.5 (1), p.113-117
Hauptverfasser: Ow, Hooisweng, Larson, Daniel R, Srivastava, Mamta, Baird, Barbara A, Webb, Watt W, Wiesner, Ulrich
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Sprache:eng
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Zusammenfassung:A class of highly fluorescent and photostable core−shell nanoparticles from a modified Stöber synthesis in the size range of 20−30 nm is described. These nanoparticles are monodisperse in solution, 20 times brighter, and more photostable than their constituent fluorophore, and are amenable to specific labeling of biological macromolecules for bioimaging experiments. The photophysical characteristics of the encapsulated fluorophores differ from their solution properties. This raises the possibility of tuning nanoparticle structure toward enhanced radiative properties, making them an attractive material platform for a diverse range of applications.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl0482478