SASPense and DDRama in cancer and ageing

Senescent cells alter their microenvironment by secreting a growing collection of factors, a phenomenon termed the senescence-associated secretory phenotype (SASP). Cellular senescence is often the result of nuclear DNA damage fuelling a chronic DNA damage response (DDR). Upstream elements of the DD...

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Veröffentlicht in:	Nature cell biology 2009-08, Vol.11 (8), p.921-923
Hauptverfasser:	Fumagalli, Marzia, d'Adda di Fagagna, Fabrizio
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Ataxia Telangiectasia Mutated Proteins Biomedical and Life Sciences Cancer Cancer Research Cell Biology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cells, Cultured Cellular Senescence - physiology Checkpoint Kinase 2 Cytokines Cytokines - secretion Deoxyribonucleic acid Developmental Biology DNA DNA Damage DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fibroblasts - cytology Fibroblasts - metabolism Fibroblasts - radiation effects Genetic aspects Humans Interleukin-6 - secretion Life Sciences Male Models, Biological news-and-views Nuclear Proteins - genetics Nuclear Proteins - metabolism Physiological aspects Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Risk factors RNA, Small Interfering - genetics Signal Transduction - physiology Stem Cells Transfection Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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Beschreibung
Zusammenfassung:	Senescent cells alter their microenvironment by secreting a growing collection of factors, a phenomenon termed the senescence-associated secretory phenotype (SASP). Cellular senescence is often the result of nuclear DNA damage fuelling a chronic DNA damage response (DDR). Upstream elements of the DDR cascade are necessary for full blown SASP, and additional crosstalk occurs between the DDR and cytokine secretion.
ISSN:	1465-7392 1476-4679
DOI:	10.1038/ncb0809-921