Parkinson's disease: in vivo assessment of disease progression using positron emission tomography

Over the past two decades, positron emission tomography (PET) has provided valuable insights into the mechanisms of nigrostriatal degeneration in Parkinson's disease (PD). Furthermore, it allows the in vivo assessment of disease progression and the evaluation of treatment interventions. In this...

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Veröffentlicht in:	Brain research. Molecular brain research. 2005-03, Vol.134 (1), p.24-33
Hauptverfasser:	Au, Wing Lok, Adams, John R., Troiano, André R., Stoessl, A. Jon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - diagnostic imaging Disease Progression Dopamine Dopamine Plasma Membrane Transport Proteins Humans Membrane Glycoproteins Membrane Transport Proteins Models, Neurological Nerve Tissue Proteins Parkinson Disease - diagnostic imaging Parkinson's disease Positron emission tomography Progression Vesicular Biogenic Amine Transport Proteins
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Zusammenfassung:	Over the past two decades, positron emission tomography (PET) has provided valuable insights into the mechanisms of nigrostriatal degeneration in Parkinson's disease (PD). Furthermore, it allows the in vivo assessment of disease progression and the evaluation of treatment interventions. In this review, we shall discuss some of the issues and concerns that arise with the use of PET as a surrogate marker of disease progression in Parkinson's disease.
ISSN:	0169-328X 1872-6941
DOI:	10.1016/j.molbrainres.2004.09.028