G-CSF Reduces Infarct Volume and Improves Functional Outcome after Transient Focal Cerebral Ischemia in Mice

G-CSF Reduces Infarct Volume and Improves Functional Outcome after Transient Focal Cerebral Ischemia in Mice

Growth factors possess neuroprotective and neurotrophic properties in vitro, but few have been extensively studied in vivo after stroke. In the present study, we investigated the potential functional benefits of granulocyte colony-stimulating factor (G-CSF) administration after focal cerebral ischem...

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Veröffentlicht in:Journal of cerebral blood flow and metabolism 2005-04, Vol.25 (4), p.431-439
Hauptverfasser: Gibson, Claire L, Bath, Philip MW, Murphy, Sean P
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antihypertensive agents
Behavior, Animal - drug effects
Biological and medical sciences
Brain - pathology
Cardiovascular system
Cerebral Infarction - drug therapy
Cerebral Infarction - pathology
Cerebrovascular Circulation - drug effects
Cognition - drug effects
Granulocyte Colony-Stimulating Factor - therapeutic use
Infarction, Middle Cerebral Artery - drug therapy
Infarction, Middle Cerebral Artery - pathology
Ischemic Attack, Transient - drug therapy
Ischemic Attack, Transient - pathology
Male
Maze Learning - drug effects
Medical sciences
Mice
Mice, Inbred C57BL
Neurology
Neuropharmacology
Neuroprotective agent
Pharmacology. Drug treatments
Postural Balance - drug effects
Psychomotor Performance - drug effects
Recombinant Proteins
Survival Analysis
Treatment Outcome
Vascular diseases and vascular malformations of the nervous system
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Zusammenfassung:Growth factors possess neuroprotective and neurotrophic properties in vitro, but few have been extensively studied in vivo after stroke. In the present study, we investigated the potential functional benefits of granulocyte colony-stimulating factor (G-CSF) administration after focal cerebral ischemia. Male mice underwent 60-minute middle cerebral artery occlusion (MCAO) and received G-CSF (50 μg/kg, subcutaneously) or vehicle (saline) at the onset of reperfusion. Granulocyte colony-stimulating factor-treated mice killed at 48 hours after MCAO revealed a >45% reduction (P
ISSN:0271-678X
1559-7016
DOI:10.1038/sj.jcbfm.9600033