Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation
alpha-Oxy/thio substituted-beta-keto esters were synthesized through an efficient cross-Claisen condensation of aryl oxy/thio acetic acid ethyl esters with acid chlorides, then it is converted in situ into 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones by the addition of hydrazine or hydrazine derivat...
Gespeichert in:
| Veröffentlicht in: | European journal of medicinal chemistry 2009-10, Vol.44 (10), p.3852-3857 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3857 |
|---|---|
| container_issue | 10 |
| container_start_page | 3852 |
| container_title | European journal of medicinal chemistry |
| container_volume | 44 |
| creator | VENKAT RAGAVAN, R VIJAYAKUMAR, V SUCHETHA KUMARI, N |
| description | alpha-Oxy/thio substituted-beta-keto esters were synthesized through an efficient cross-Claisen condensation of aryl oxy/thio acetic acid ethyl esters with acid chlorides, then it is converted in situ into 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones by the addition of hydrazine or hydrazine derivatives and screened for their antibacterial, antifungal activities. |
| doi_str_mv | 10.1016/j.ejmech.2009.04.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67542728</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67542728</sourcerecordid><originalsourceid>FETCH-LOGICAL-c335t-603f85c1170a7060616a2bef7803400fbe8a57f1ec90807f95c66ca77289b123</originalsourceid><addsrcrecordid>eNpFkE2P0zAURS0EYsrAP0DIGxAsnHn-TLJEFVCkkVgwe8txn1VXqV1ip1B-PRlawepuzr26OoS85tBw4OZu3-D-gH7XCIC-AdUAhydkxVvTMSm0ekpWIIRkWkh1Q16UsgcAbQCekxveKyF5r1fk5_dzqjsssdAcaMkHpCmfcKRDzM7XeEKqWP51vqu7mGmZh1JjnStuGd-w43lyv_PI9Hu1-cBywkJP0VEMIfqIqVI_5VLYenSxYKI-py2m4mrM6SV5FtxY8NU1b8nD508P6w27__bl6_rjPfNS6soMyNBpz3kLrgUDhhsnBgxtB1IBhAE7p9vA0ffQQRt67Y3xrm1F1w9cyFvy7jJ7nPKPGUu1h1g8jqNLmOdiTauVWOAFVBfw7-UJgz1O8eCms-VgH33bvb34to--LSi7-F5qb67783DA7f_SVfACvL0Crng3hsklH8s_TvBO9EIZ-QfCT4rw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67542728</pqid></control><display><type>article</type><title>Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>VENKAT RAGAVAN, R ; VIJAYAKUMAR, V ; SUCHETHA KUMARI, N</creator><creatorcontrib>VENKAT RAGAVAN, R ; VIJAYAKUMAR, V ; SUCHETHA KUMARI, N</creatorcontrib><description>alpha-Oxy/thio substituted-beta-keto esters were synthesized through an efficient cross-Claisen condensation of aryl oxy/thio acetic acid ethyl esters with acid chlorides, then it is converted in situ into 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones by the addition of hydrazine or hydrazine derivatives and screened for their antibacterial, antifungal activities.</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/j.ejmech.2009.04.010</identifier><identifier>PMID: 19423195</identifier><identifier>CODEN: EJMCA5</identifier><language>eng</language><publisher>Kidlington: Elsevier</publisher><subject>Anti-Bacterial Agents - chemical synthesis ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Antifungal Agents - chemical synthesis ; Antifungal Agents - chemistry ; Antifungal Agents - pharmacology ; Bacteria - drug effects ; Biological and medical sciences ; Fungi - drug effects ; General aspects ; Medical sciences ; Microbial Sensitivity Tests ; Pharmacology. Drug treatments ; Pyrazolones - chemical synthesis ; Pyrazolones - chemistry ; Pyrazolones - pharmacology ; Structure-Activity Relationship</subject><ispartof>European journal of medicinal chemistry, 2009-10, Vol.44 (10), p.3852-3857</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-603f85c1170a7060616a2bef7803400fbe8a57f1ec90807f95c66ca77289b123</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21829246$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19423195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VENKAT RAGAVAN, R</creatorcontrib><creatorcontrib>VIJAYAKUMAR, V</creatorcontrib><creatorcontrib>SUCHETHA KUMARI, N</creatorcontrib><title>Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation</title><title>European journal of medicinal chemistry</title><addtitle>Eur J Med Chem</addtitle><description>alpha-Oxy/thio substituted-beta-keto esters were synthesized through an efficient cross-Claisen condensation of aryl oxy/thio acetic acid ethyl esters with acid chlorides, then it is converted in situ into 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones by the addition of hydrazine or hydrazine derivatives and screened for their antibacterial, antifungal activities.</description><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - chemical synthesis</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - pharmacology</subject><subject>Bacteria - drug effects</subject><subject>Biological and medical sciences</subject><subject>Fungi - drug effects</subject><subject>General aspects</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrazolones - chemical synthesis</subject><subject>Pyrazolones - chemistry</subject><subject>Pyrazolones - pharmacology</subject><subject>Structure-Activity Relationship</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE2P0zAURS0EYsrAP0DIGxAsnHn-TLJEFVCkkVgwe8txn1VXqV1ip1B-PRlawepuzr26OoS85tBw4OZu3-D-gH7XCIC-AdUAhydkxVvTMSm0ekpWIIRkWkh1Q16UsgcAbQCekxveKyF5r1fk5_dzqjsssdAcaMkHpCmfcKRDzM7XeEKqWP51vqu7mGmZh1JjnStuGd-w43lyv_PI9Hu1-cBywkJP0VEMIfqIqVI_5VLYenSxYKI-py2m4mrM6SV5FtxY8NU1b8nD508P6w27__bl6_rjPfNS6soMyNBpz3kLrgUDhhsnBgxtB1IBhAE7p9vA0ffQQRt67Y3xrm1F1w9cyFvy7jJ7nPKPGUu1h1g8jqNLmOdiTauVWOAFVBfw7-UJgz1O8eCms-VgH33bvb34to--LSi7-F5qb67783DA7f_SVfACvL0Crng3hsklH8s_TvBO9EIZ-QfCT4rw</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>VENKAT RAGAVAN, R</creator><creator>VIJAYAKUMAR, V</creator><creator>SUCHETHA KUMARI, N</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091001</creationdate><title>Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation</title><author>VENKAT RAGAVAN, R ; VIJAYAKUMAR, V ; SUCHETHA KUMARI, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-603f85c1170a7060616a2bef7803400fbe8a57f1ec90807f95c66ca77289b123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Anti-Bacterial Agents - chemical synthesis</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - chemical synthesis</topic><topic>Antifungal Agents - chemistry</topic><topic>Antifungal Agents - pharmacology</topic><topic>Bacteria - drug effects</topic><topic>Biological and medical sciences</topic><topic>Fungi - drug effects</topic><topic>General aspects</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrazolones - chemical synthesis</topic><topic>Pyrazolones - chemistry</topic><topic>Pyrazolones - pharmacology</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VENKAT RAGAVAN, R</creatorcontrib><creatorcontrib>VIJAYAKUMAR, V</creatorcontrib><creatorcontrib>SUCHETHA KUMARI, N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VENKAT RAGAVAN, R</au><au>VIJAYAKUMAR, V</au><au>SUCHETHA KUMARI, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>44</volume><issue>10</issue><spage>3852</spage><epage>3857</epage><pages>3852-3857</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><coden>EJMCA5</coden><abstract>alpha-Oxy/thio substituted-beta-keto esters were synthesized through an efficient cross-Claisen condensation of aryl oxy/thio acetic acid ethyl esters with acid chlorides, then it is converted in situ into 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones by the addition of hydrazine or hydrazine derivatives and screened for their antibacterial, antifungal activities.</abstract><cop>Kidlington</cop><pub>Elsevier</pub><pmid>19423195</pmid><doi>10.1016/j.ejmech.2009.04.010</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0223-5234 |
| ispartof | European journal of medicinal chemistry, 2009-10, Vol.44 (10), p.3852-3857 |
| issn | 0223-5234 1768-3254 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67542728 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Bacteria - drug effects Biological and medical sciences Fungi - drug effects General aspects Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Pyrazolones - chemical synthesis Pyrazolones - chemistry Pyrazolones - pharmacology Structure-Activity Relationship |
| title | Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T09%3A18%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20of%20some%20novel%20bioactive%204-oxy/thio%20substituted-1H-pyrazol-5(4H)-ones%20via%20efficient%20cross-Claisen%20condensation&rft.jtitle=European%20journal%20of%20medicinal%20chemistry&rft.au=VENKAT%20RAGAVAN,%20R&rft.date=2009-10-01&rft.volume=44&rft.issue=10&rft.spage=3852&rft.epage=3857&rft.pages=3852-3857&rft.issn=0223-5234&rft.eissn=1768-3254&rft.coden=EJMCA5&rft_id=info:doi/10.1016/j.ejmech.2009.04.010&rft_dat=%3Cproquest_cross%3E67542728%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67542728&rft_id=info:pmid/19423195&rfr_iscdi=true |