Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation

alpha-Oxy/thio substituted-beta-keto esters were synthesized through an efficient cross-Claisen condensation of aryl oxy/thio acetic acid ethyl esters with acid chlorides, then it is converted in situ into 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones by the addition of hydrazine or hydrazine derivat...

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Veröffentlicht in:	European journal of medicinal chemistry 2009-10, Vol.44 (10), p.3852-3857
Hauptverfasser:	VENKAT RAGAVAN, R, VIJAYAKUMAR, V, SUCHETHA KUMARI, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Bacteria - drug effects Biological and medical sciences Fungi - drug effects General aspects Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Pyrazolones - chemical synthesis Pyrazolones - chemistry Pyrazolones - pharmacology Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	alpha-Oxy/thio substituted-beta-keto esters were synthesized through an efficient cross-Claisen condensation of aryl oxy/thio acetic acid ethyl esters with acid chlorides, then it is converted in situ into 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones by the addition of hydrazine or hydrazine derivatives and screened for their antibacterial, antifungal activities.
ISSN:	0223-5234 1768-3254
DOI:	10.1016/j.ejmech.2009.04.010