Nasopharyngeal Carriage of Streptococcus pneumoniae in Navajo and White Mountain Apache Children Before the Introduction of Pneumococcal Conjugate Vaccine
BACKGROUND:Infants and children are frequently colonized with pneumococcus. Recent nasopharyngeal acquisition of pneumococcus is thought to precede disease episodes. The increased risk of pneumococcal disease among Navajo and White Mountain Apache populations has been documented. Little is known abo...
Gespeichert in:
| Veröffentlicht in: | The Pediatric infectious disease journal 2009-08, Vol.28 (8), p.711-716 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 716 |
|---|---|
| container_issue | 8 |
| container_start_page | 711 |
| container_title | The Pediatric infectious disease journal |
| container_volume | 28 |
| creator | Millar, Eugene V OʼBrien, Katherine L Zell, Elizabeth R Bronsdon, Melinda A Reid, Raymond Santosham, Mathuram |
| description | BACKGROUND:Infants and children are frequently colonized with pneumococcus. Recent nasopharyngeal acquisition of pneumococcus is thought to precede disease episodes. The increased risk of pneumococcal disease among Navajo and White Mountain Apache populations has been documented. Little is known about the dynamics of pneumococcal carriage in these populations.
METHODS:A group randomized, controlled trial of 7-valent conjugate pneumococcal vaccine (PnCRM7, Wyeth) was conducted on the Navajo and Apache reservations. A nasopharyngeal (NP) carriage study was nested in the trial to evaluate the impact of PnCRM7 on carriage. Children |
| doi_str_mv | 10.1097/INF.0b013e3181a06303 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67540936</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67540936</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3801-7a31f5474b9cb447567546c4521f4f9ccab9fc8fc5d5fe2caceda00bc1f43ff13</originalsourceid><addsrcrecordid>eNpdkdtu1DAQhiMEokvhDRDyDdyljGM7h8uyorBSWZA4XUYTZ7zxkrVTO6HiVXhavHRFJS4sy55_vpHmy7LnHC44NNXrzfbqAjrgggSvOUIpQDzIVlyJIoemrh5mK6gbnouyrM-yJzHuAUBIDo-zM96oRhSyXmW_txj9NGD45XaEI1tjCBZ3xLxhn-dA0-y113qJbHK0HLyzSMw6tsWfuPcMXc--D3Ym9sEvbsZUuZxQD8TWgx37QI69IeMDsTn9bdwcfL_o2Xp3HPDpL_LIP072br_sMKG-odbW0dPskcEx0rPTfZ59vXr7Zf0-v_74brO-vM61qIHnFQpulKxk1-hOykqVlZKllqrgRpomsbvG6Npo1StDhUZNPQJ0OpWFMVycZ6_uuFPwNwvFuT3YqGkc0ZFfYnvkQSPKFJR3QR18jIFMOwV7SKtrObRHJ21y0v7vJLW9OPGX7kD9fdNJQgq8PAUwpk2YgE7b-C9X8LoApYr7-bd-nCnEH-NyS6Edkrd5aJNdKKWSeQHQQJ1eeTqciz_-HqiY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67540936</pqid></control><display><type>article</type><title>Nasopharyngeal Carriage of Streptococcus pneumoniae in Navajo and White Mountain Apache Children Before the Introduction of Pneumococcal Conjugate Vaccine</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Millar, Eugene V ; OʼBrien, Katherine L ; Zell, Elizabeth R ; Bronsdon, Melinda A ; Reid, Raymond ; Santosham, Mathuram</creator><creatorcontrib>Millar, Eugene V ; OʼBrien, Katherine L ; Zell, Elizabeth R ; Bronsdon, Melinda A ; Reid, Raymond ; Santosham, Mathuram</creatorcontrib><description>BACKGROUND:Infants and children are frequently colonized with pneumococcus. Recent nasopharyngeal acquisition of pneumococcus is thought to precede disease episodes. The increased risk of pneumococcal disease among Navajo and White Mountain Apache populations has been documented. Little is known about the dynamics of pneumococcal carriage in these populations.
METHODS:A group randomized, controlled trial of 7-valent conjugate pneumococcal vaccine (PnCRM7, Wyeth) was conducted on the Navajo and Apache reservations. A nasopharyngeal (NP) carriage study was nested in the trial to evaluate the impact of PnCRM7 on carriage. Children <6 years of age had NP swabs collected at enrollment and at 6 and 12 months following enrollment. We analyzed carriage data from children in control vaccine randomized communities to describe the epidemiology of pneumococcal carriage.
RESULTS:Of the 410 participants enrolled, 92% were colonized with pneumococcus at least once during the course of the study. Sixty-three percent of NP specimens were positive for pneumococcus. The most common serotypes were 6A, 6B, nontypable, 23F, 14, 19F, 19A, and 9V. Thirty-eight percent of isolates were vaccine serotypes. Age <2 years, male sex, daycare attendance, and having a sibling colonized with pneumococcus were associated with an increased risk of carriage.
CONCLUSIONS:The high carriage prevalence among Navajo and Apache children reflects an intense exposure to pneumococcus. The lack of modifiable risk factors for carriage highlights the importance of preventive strategies for disease control.</description><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 1532-0987</identifier><identifier>DOI: 10.1097/INF.0b013e3181a06303</identifier><identifier>PMID: 19593248</identifier><identifier>CODEN: PIDJEV</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Age Factors ; Bacterial diseases ; Biological and medical sciences ; Carrier State - epidemiology ; Carrier State - microbiology ; Carrier State - prevention & control ; Female ; Heptavalent Pneumococcal Conjugate Vaccine ; Human bacterial diseases ; Humans ; Indians, North American ; Infant ; Infectious diseases ; Male ; Medical sciences ; Multivariate Analysis ; Nasopharynx - microbiology ; Pneumococcal Infections - epidemiology ; Pneumococcal Infections - microbiology ; Pneumococcal Infections - prevention & control ; Pneumococcal Vaccines - administration & dosage ; Pneumococcal Vaccines - immunology ; Prevalence ; Risk Factors ; Serotyping ; Southwestern United States ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Streptococcus pneumoniae - isolation & purification</subject><ispartof>The Pediatric infectious disease journal, 2009-08, Vol.28 (8), p.711-716</ispartof><rights>2009 Lippincott Williams & Wilkins, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3801-7a31f5474b9cb447567546c4521f4f9ccab9fc8fc5d5fe2caceda00bc1f43ff13</citedby><cites>FETCH-LOGICAL-c3801-7a31f5474b9cb447567546c4521f4f9ccab9fc8fc5d5fe2caceda00bc1f43ff13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21820552$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19593248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Millar, Eugene V</creatorcontrib><creatorcontrib>OʼBrien, Katherine L</creatorcontrib><creatorcontrib>Zell, Elizabeth R</creatorcontrib><creatorcontrib>Bronsdon, Melinda A</creatorcontrib><creatorcontrib>Reid, Raymond</creatorcontrib><creatorcontrib>Santosham, Mathuram</creatorcontrib><title>Nasopharyngeal Carriage of Streptococcus pneumoniae in Navajo and White Mountain Apache Children Before the Introduction of Pneumococcal Conjugate Vaccine</title><title>The Pediatric infectious disease journal</title><addtitle>Pediatr Infect Dis J</addtitle><description>BACKGROUND:Infants and children are frequently colonized with pneumococcus. Recent nasopharyngeal acquisition of pneumococcus is thought to precede disease episodes. The increased risk of pneumococcal disease among Navajo and White Mountain Apache populations has been documented. Little is known about the dynamics of pneumococcal carriage in these populations.
METHODS:A group randomized, controlled trial of 7-valent conjugate pneumococcal vaccine (PnCRM7, Wyeth) was conducted on the Navajo and Apache reservations. A nasopharyngeal (NP) carriage study was nested in the trial to evaluate the impact of PnCRM7 on carriage. Children <6 years of age had NP swabs collected at enrollment and at 6 and 12 months following enrollment. We analyzed carriage data from children in control vaccine randomized communities to describe the epidemiology of pneumococcal carriage.
RESULTS:Of the 410 participants enrolled, 92% were colonized with pneumococcus at least once during the course of the study. Sixty-three percent of NP specimens were positive for pneumococcus. The most common serotypes were 6A, 6B, nontypable, 23F, 14, 19F, 19A, and 9V. Thirty-eight percent of isolates were vaccine serotypes. Age <2 years, male sex, daycare attendance, and having a sibling colonized with pneumococcus were associated with an increased risk of carriage.
CONCLUSIONS:The high carriage prevalence among Navajo and Apache children reflects an intense exposure to pneumococcus. The lack of modifiable risk factors for carriage highlights the importance of preventive strategies for disease control.</description><subject>Age Factors</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Carrier State - epidemiology</subject><subject>Carrier State - microbiology</subject><subject>Carrier State - prevention & control</subject><subject>Female</subject><subject>Heptavalent Pneumococcal Conjugate Vaccine</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Indians, North American</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Nasopharynx - microbiology</subject><subject>Pneumococcal Infections - epidemiology</subject><subject>Pneumococcal Infections - microbiology</subject><subject>Pneumococcal Infections - prevention & control</subject><subject>Pneumococcal Vaccines - administration & dosage</subject><subject>Pneumococcal Vaccines - immunology</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Serotyping</subject><subject>Southwestern United States</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Streptococcus pneumoniae - isolation & purification</subject><issn>0891-3668</issn><issn>1532-0987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdtu1DAQhiMEokvhDRDyDdyljGM7h8uyorBSWZA4XUYTZ7zxkrVTO6HiVXhavHRFJS4sy55_vpHmy7LnHC44NNXrzfbqAjrgggSvOUIpQDzIVlyJIoemrh5mK6gbnouyrM-yJzHuAUBIDo-zM96oRhSyXmW_txj9NGD45XaEI1tjCBZ3xLxhn-dA0-y113qJbHK0HLyzSMw6tsWfuPcMXc--D3Ym9sEvbsZUuZxQD8TWgx37QI69IeMDsTn9bdwcfL_o2Xp3HPDpL_LIP072br_sMKG-odbW0dPskcEx0rPTfZ59vXr7Zf0-v_74brO-vM61qIHnFQpulKxk1-hOykqVlZKllqrgRpomsbvG6Npo1StDhUZNPQJ0OpWFMVycZ6_uuFPwNwvFuT3YqGkc0ZFfYnvkQSPKFJR3QR18jIFMOwV7SKtrObRHJ21y0v7vJLW9OPGX7kD9fdNJQgq8PAUwpk2YgE7b-C9X8LoApYr7-bd-nCnEH-NyS6Edkrd5aJNdKKWSeQHQQJ1eeTqciz_-HqiY</recordid><startdate>200908</startdate><enddate>200908</enddate><creator>Millar, Eugene V</creator><creator>OʼBrien, Katherine L</creator><creator>Zell, Elizabeth R</creator><creator>Bronsdon, Melinda A</creator><creator>Reid, Raymond</creator><creator>Santosham, Mathuram</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200908</creationdate><title>Nasopharyngeal Carriage of Streptococcus pneumoniae in Navajo and White Mountain Apache Children Before the Introduction of Pneumococcal Conjugate Vaccine</title><author>Millar, Eugene V ; OʼBrien, Katherine L ; Zell, Elizabeth R ; Bronsdon, Melinda A ; Reid, Raymond ; Santosham, Mathuram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3801-7a31f5474b9cb447567546c4521f4f9ccab9fc8fc5d5fe2caceda00bc1f43ff13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Age Factors</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Carrier State - epidemiology</topic><topic>Carrier State - microbiology</topic><topic>Carrier State - prevention & control</topic><topic>Female</topic><topic>Heptavalent Pneumococcal Conjugate Vaccine</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Indians, North American</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Nasopharynx - microbiology</topic><topic>Pneumococcal Infections - epidemiology</topic><topic>Pneumococcal Infections - microbiology</topic><topic>Pneumococcal Infections - prevention & control</topic><topic>Pneumococcal Vaccines - administration & dosage</topic><topic>Pneumococcal Vaccines - immunology</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Serotyping</topic><topic>Southwestern United States</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Streptococcus pneumoniae - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Millar, Eugene V</creatorcontrib><creatorcontrib>OʼBrien, Katherine L</creatorcontrib><creatorcontrib>Zell, Elizabeth R</creatorcontrib><creatorcontrib>Bronsdon, Melinda A</creatorcontrib><creatorcontrib>Reid, Raymond</creatorcontrib><creatorcontrib>Santosham, Mathuram</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Pediatric infectious disease journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Millar, Eugene V</au><au>OʼBrien, Katherine L</au><au>Zell, Elizabeth R</au><au>Bronsdon, Melinda A</au><au>Reid, Raymond</au><au>Santosham, Mathuram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nasopharyngeal Carriage of Streptococcus pneumoniae in Navajo and White Mountain Apache Children Before the Introduction of Pneumococcal Conjugate Vaccine</atitle><jtitle>The Pediatric infectious disease journal</jtitle><addtitle>Pediatr Infect Dis J</addtitle><date>2009-08</date><risdate>2009</risdate><volume>28</volume><issue>8</issue><spage>711</spage><epage>716</epage><pages>711-716</pages><issn>0891-3668</issn><eissn>1532-0987</eissn><coden>PIDJEV</coden><abstract>BACKGROUND:Infants and children are frequently colonized with pneumococcus. Recent nasopharyngeal acquisition of pneumococcus is thought to precede disease episodes. The increased risk of pneumococcal disease among Navajo and White Mountain Apache populations has been documented. Little is known about the dynamics of pneumococcal carriage in these populations.
METHODS:A group randomized, controlled trial of 7-valent conjugate pneumococcal vaccine (PnCRM7, Wyeth) was conducted on the Navajo and Apache reservations. A nasopharyngeal (NP) carriage study was nested in the trial to evaluate the impact of PnCRM7 on carriage. Children <6 years of age had NP swabs collected at enrollment and at 6 and 12 months following enrollment. We analyzed carriage data from children in control vaccine randomized communities to describe the epidemiology of pneumococcal carriage.
RESULTS:Of the 410 participants enrolled, 92% were colonized with pneumococcus at least once during the course of the study. Sixty-three percent of NP specimens were positive for pneumococcus. The most common serotypes were 6A, 6B, nontypable, 23F, 14, 19F, 19A, and 9V. Thirty-eight percent of isolates were vaccine serotypes. Age <2 years, male sex, daycare attendance, and having a sibling colonized with pneumococcus were associated with an increased risk of carriage.
CONCLUSIONS:The high carriage prevalence among Navajo and Apache children reflects an intense exposure to pneumococcus. The lack of modifiable risk factors for carriage highlights the importance of preventive strategies for disease control.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>19593248</pmid><doi>10.1097/INF.0b013e3181a06303</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0891-3668 |
| ispartof | The Pediatric infectious disease journal, 2009-08, Vol.28 (8), p.711-716 |
| issn | 0891-3668 1532-0987 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67540936 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Age Factors Bacterial diseases Biological and medical sciences Carrier State - epidemiology Carrier State - microbiology Carrier State - prevention & control Female Heptavalent Pneumococcal Conjugate Vaccine Human bacterial diseases Humans Indians, North American Infant Infectious diseases Male Medical sciences Multivariate Analysis Nasopharynx - microbiology Pneumococcal Infections - epidemiology Pneumococcal Infections - microbiology Pneumococcal Infections - prevention & control Pneumococcal Vaccines - administration & dosage Pneumococcal Vaccines - immunology Prevalence Risk Factors Serotyping Southwestern United States Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcus pneumoniae - isolation & purification |
| title | Nasopharyngeal Carriage of Streptococcus pneumoniae in Navajo and White Mountain Apache Children Before the Introduction of Pneumococcal Conjugate Vaccine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T16%3A20%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nasopharyngeal%20Carriage%20of%20Streptococcus%20pneumoniae%20in%20Navajo%20and%20White%20Mountain%20Apache%20Children%20Before%20the%20Introduction%20of%20Pneumococcal%20Conjugate%20Vaccine&rft.jtitle=The%20Pediatric%20infectious%20disease%20journal&rft.au=Millar,%20Eugene%20V&rft.date=2009-08&rft.volume=28&rft.issue=8&rft.spage=711&rft.epage=716&rft.pages=711-716&rft.issn=0891-3668&rft.eissn=1532-0987&rft.coden=PIDJEV&rft_id=info:doi/10.1097/INF.0b013e3181a06303&rft_dat=%3Cproquest_cross%3E67540936%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67540936&rft_id=info:pmid/19593248&rfr_iscdi=true |