Nasopharyngeal Carriage of Streptococcus pneumoniae in Navajo and White Mountain Apache Children Before the Introduction of Pneumococcal Conjugate Vaccine

BACKGROUND:Infants and children are frequently colonized with pneumococcus. Recent nasopharyngeal acquisition of pneumococcus is thought to precede disease episodes. The increased risk of pneumococcal disease among Navajo and White Mountain Apache populations has been documented. Little is known abo...

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Veröffentlicht in:	The Pediatric infectious disease journal 2009-08, Vol.28 (8), p.711-716
Hauptverfasser:	Millar, Eugene V, OʼBrien, Katherine L, Zell, Elizabeth R, Bronsdon, Melinda A, Reid, Raymond, Santosham, Mathuram
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Bacterial diseases Biological and medical sciences Carrier State - epidemiology Carrier State - microbiology Carrier State - prevention & control Female Heptavalent Pneumococcal Conjugate Vaccine Human bacterial diseases Humans Indians, North American Infant Infectious diseases Male Medical sciences Multivariate Analysis Nasopharynx - microbiology Pneumococcal Infections - epidemiology Pneumococcal Infections - microbiology Pneumococcal Infections - prevention & control Pneumococcal Vaccines - administration & dosage Pneumococcal Vaccines - immunology Prevalence Risk Factors Serotyping Southwestern United States Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcus pneumoniae - isolation & purification
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Zusammenfassung:	BACKGROUND:Infants and children are frequently colonized with pneumococcus. Recent nasopharyngeal acquisition of pneumococcus is thought to precede disease episodes. The increased risk of pneumococcal disease among Navajo and White Mountain Apache populations has been documented. Little is known about the dynamics of pneumococcal carriage in these populations. METHODS:A group randomized, controlled trial of 7-valent conjugate pneumococcal vaccine (PnCRM7, Wyeth) was conducted on the Navajo and Apache reservations. A nasopharyngeal (NP) carriage study was nested in the trial to evaluate the impact of PnCRM7 on carriage. Children
ISSN:	0891-3668 1532-0987
DOI:	10.1097/INF.0b013e3181a06303