Migraine, headache, and the risk of stroke in women : A prospective study

Migraine and headache in general have been associated with subsequent risk of stroke, primarily in retrospective case-control studies. Prospective data evaluating the association between specific headache forms and stroke are sparse. A prospective cohort study was conducted among 39,754 US health pr...

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Veröffentlicht in:Neurology 2005-03, Vol.64 (6), p.1020-1026
Hauptverfasser: KURTH, T, SLOMKE, M. A, KASE, C. S, COOK, N. R, LEE, I.-M, GAZIANO, J. M, DIENER, H.-C, BURING, J. E
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Sprache:eng
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Zusammenfassung:Migraine and headache in general have been associated with subsequent risk of stroke, primarily in retrospective case-control studies. Prospective data evaluating the association between specific headache forms and stroke are sparse. A prospective cohort study was conducted among 39,754 US health professionals age 45 and older participating in the Women's Health Study with an average follow-up of 9 years. Incident stroke was self-reported and confirmed by medical record review. A total of 385 strokes (309 ischemic, 72 hemorrhagic, and 4 undefined) occurred. Compared with nonmigraineurs, participants who reported migraine overall or migraine without aura had no increased risk of any stroke type. Participants who reported migraine with aura had increased adjusted hazards ratios (HRs) of 1.53 (95% CI 1.02 to 2.31) for total stroke and 1.71 (95% CI 1.11 to 2.66) for ischemic stroke but no increased risk for hemorrhagic stroke. Participants with migraine with aura who were
ISSN:0028-3878
1526-632X
DOI:10.1212/01.WNL.0000154528.21485.3A