Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample

Recently, the DAOA gene locus on chromosome 13q32–q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically signific...

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Veröffentlicht in:	Neuroscience letters 2009-09, Vol.462 (2), p.105-108
Hauptverfasser:	Ma, Jie, Sun, Jian, Zhang, Huan, Zhang, Rui, Kang, Wan-Hu, Gao, Cheng-Ge, Liu, Hai-Sheng, Ma, Xue-Hong, Min, Zi-Xin, Zhao, Wen-Xiang, Ning, Qi-Lan, Wang, Shu-Hong, Zhang, Yin-Cang, Guo, Ting-Wei, Lu, She-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Association Biological and medical sciences Carrier Proteins - genetics DAOA Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Genotype Haplotype Haplotypes Humans Linkage Disequilibrium Male Medical sciences Pedigree Polymerase Chain Reaction Polymorphism, Single Nucleotide Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - genetics SNP TDT Vertebrates: nervous system and sense organs
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Zusammenfassung:	Recently, the DAOA gene locus on chromosome 13q32–q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 ( P = 0.01) and rs3918342 ( P = 0.02), and a highly significant under-transmission between haplotype CAT ( P = 0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2009.06.070