The Prospect of Silencing Disease Using RNA Interference
The discovery of RNA interference (RNAi), an endogenous cellular gene-silencing mechanism, has already provided a powerful tool for basic science researchers to study gene function. The subsequent finding that RNAi also operates in mammalian cells has generated excitement regarding potential therape...
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| Veröffentlicht in: | JAMA : the journal of the American Medical Association 2005-03, Vol.293 (11), p.1367-1373 |
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| container_title | JAMA : the journal of the American Medical Association |
| container_volume | 293 |
| creator | Shankar, Premlata Manjunath, N Lieberman, Judy |
| description | The discovery of RNA interference (RNAi), an endogenous cellular gene-silencing
mechanism, has already provided a powerful tool for basic science researchers
to study gene function. The subsequent finding that RNAi also operates in
mammalian cells has generated excitement regarding potential therapeutic applications.
In this article we discuss the basic mechanism of RNAi and the therapeutic
opportunities and obstacles for harnessing RNAi for therapy of human disease. |
| doi_str_mv | 10.1001/jama.293.11.1367 |
| format | Article |
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to study gene function. The subsequent finding that RNAi also operates in
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In this article we discuss the basic mechanism of RNAi and the therapeutic
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to study gene function. The subsequent finding that RNAi also operates in
mammalian cells has generated excitement regarding potential therapeutic applications.
In this article we discuss the basic mechanism of RNAi and the therapeutic
opportunities and obstacles for harnessing RNAi for therapy of human disease.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Disease</subject><subject>Gene therapy</subject><subject>General aspects</subject><subject>Genetic Therapy</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Neoplasms - therapy</subject><subject>Nervous System Diseases - therapy</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA Interference - physiology</subject><subject>Virus Diseases - therapy</subject><issn>0098-7484</issn><issn>1538-3598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1LwzAYBvAgipvTu16kCHprzZvvHMf8hKGi27mkaaod_ZhNe_C_N7Kp4MVcQsiPJ7xPEDoGnADGcLkytUmIpglAAlTIHTQGTlVMuVa7aIyxVrFkio3QgfcrHBZQuY9GwKXQWuIxUos3Fz11rV8720dtEb2UlWts2bxGV6V3xrto6b9Ozw_T6L7pXVe4LgB3iPYKU3l3tN0naHlzvZjdxfPH2_vZdB4bRlQfK5pLpQwDhY0K71OZaZFl1tqcWdCWFCIzWmUs05oBLwjjJM-F0pJgbcDRCbrY5K679n1wvk_r0ltXVaZx7eBTITnhIgT_B0EqrIjWAZ79gat26JowREoAGCObtNMtGrLa5em6K2vTfaTfzQVwvgXGW1MVnQmt-V8nuA7Fi-BONi581c8twZiDpp8f9IJo</recordid><startdate>20050316</startdate><enddate>20050316</enddate><creator>Shankar, Premlata</creator><creator>Manjunath, N</creator><creator>Lieberman, Judy</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20050316</creationdate><title>The Prospect of Silencing Disease Using RNA Interference</title><author>Shankar, Premlata ; 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mechanism, has already provided a powerful tool for basic science researchers
to study gene function. The subsequent finding that RNAi also operates in
mammalian cells has generated excitement regarding potential therapeutic applications.
In this article we discuss the basic mechanism of RNAi and the therapeutic
opportunities and obstacles for harnessing RNAi for therapy of human disease.</abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>15769970</pmid><doi>10.1001/jama.293.11.1367</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0098-7484 |
| ispartof | JAMA : the journal of the American Medical Association, 2005-03, Vol.293 (11), p.1367-1373 |
| issn | 0098-7484 1538-3598 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67525600 |
| source | MEDLINE; American Medical Association Journals |
| subjects | Animals Biological and medical sciences Disease Gene therapy General aspects Genetic Therapy Humans Medical sciences Medical treatment Neoplasms - therapy Nervous System Diseases - therapy Ribonucleic acid RNA RNA Interference - physiology Virus Diseases - therapy |
| title | The Prospect of Silencing Disease Using RNA Interference |
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