The Prospect of Silencing Disease Using RNA Interference

The discovery of RNA interference (RNAi), an endogenous cellular gene-silencing mechanism, has already provided a powerful tool for basic science researchers to study gene function. The subsequent finding that RNAi also operates in mammalian cells has generated excitement regarding potential therape...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2005-03, Vol.293 (11), p.1367-1373
Hauptverfasser:	Shankar, Premlata, Manjunath, N, Lieberman, Judy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Disease Gene therapy General aspects Genetic Therapy Humans Medical sciences Medical treatment Neoplasms - therapy Nervous System Diseases - therapy Ribonucleic acid RNA RNA Interference - physiology Virus Diseases - therapy
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Beschreibung
Zusammenfassung:	The discovery of RNA interference (RNAi), an endogenous cellular gene-silencing mechanism, has already provided a powerful tool for basic science researchers to study gene function. The subsequent finding that RNAi also operates in mammalian cells has generated excitement regarding potential therapeutic applications. In this article we discuss the basic mechanism of RNAi and the therapeutic opportunities and obstacles for harnessing RNAi for therapy of human disease.
ISSN:	0098-7484 1538-3598
DOI:	10.1001/jama.293.11.1367