High Glucose Levels Abolish Antiatherosclerotic Benefits of ACE Inhibition in Alloxan-Induced Diabetes in Rabbits

Renin-angiotensin system activation is recognized to play an important role in atherosclerosis. This study aimed to verify the antiatherosclerotic effects of ACE inhibition on an experimental model of diabetes and hypercholesterolemia. Diabetes was induced in New Zealand male rabbits with a single d...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2005-04, Vol.45 (4), p.295-300
Hauptverfasser:	Pomaro, Daniel R, Ihara, Silvia S. M, Pinto, Leonor E. S. A, Ueda, Ivete, Casarini, Dulce E, Ebihara, Fabiana, Santos, Andreza O, Izar, Maria C. O, Fonseca, Francisco A. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals Arteriosclerosis - blood Arteriosclerosis - drug therapy Blood Glucose - drug effects Blood Glucose - metabolism Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Hypercholesterolemia - blood Hypercholesterolemia - drug therapy Male Quinapril Rabbits Tetrahydroisoquinolines - pharmacology Tetrahydroisoquinolines - therapeutic use
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