High Glucose Levels Abolish Antiatherosclerotic Benefits of ACE Inhibition in Alloxan-Induced Diabetes in Rabbits

Renin-angiotensin system activation is recognized to play an important role in atherosclerosis. This study aimed to verify the antiatherosclerotic effects of ACE inhibition on an experimental model of diabetes and hypercholesterolemia. Diabetes was induced in New Zealand male rabbits with a single d...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cardiovascular pharmacology 2005-04, Vol.45 (4), p.295-300
Hauptverfasser:	Pomaro, Daniel R, Ihara, Silvia S. M, Pinto, Leonor E. S. A, Ueda, Ivete, Casarini, Dulce E, Ebihara, Fabiana, Santos, Andreza O, Izar, Maria C. O, Fonseca, Francisco A. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals Arteriosclerosis - blood Arteriosclerosis - drug therapy Blood Glucose - drug effects Blood Glucose - metabolism Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Hypercholesterolemia - blood Hypercholesterolemia - drug therapy Male Quinapril Rabbits Tetrahydroisoquinolines - pharmacology Tetrahydroisoquinolines - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Renin-angiotensin system activation is recognized to play an important role in atherosclerosis. This study aimed to verify the antiatherosclerotic effects of ACE inhibition on an experimental model of diabetes and hypercholesterolemia. Diabetes was induced in New Zealand male rabbits with a single dose of alloxan (100 mg/kg, IV), and, according to plasma glucose levels obtained after 1 week, the animals were divided into 2 groups (≥250 mg/dL or
ISSN:	0160-2446 1533-4023
DOI:	10.1097/01.fjc.0000155384.64350.45