MicroRNAs in Cancer

MicroRNAs in Cancer

MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion, mutation, and epigenetic silencing. Several...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Annual review of medicine 2009-01, Vol.60 (1), p.167-179
Hauptverfasser: Garzon, Ramiro, Calin, George A, Croce, Carlo M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Apoptosis
Cancer
Cell cycle
Epigenesis, Genetic
Genes, Tumor Suppressor - physiology
Humans
Medical diagnosis
Medical prognosis
MicroRNAs - physiology
Neoplasms - genetics
Oncogenes - physiology
Oncology
Prognosis
Ribonucleic acid
RNA
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion, mutation, and epigenetic silencing. Several studies have now shown that miRNAs are involved in the initiation and progression of cancer. In this review, we briefly describe miRNA biogenesis and discuss how miRNAs can act as oncogenes and tumor suppressors. We also address the role of miRNAs in the diagnosis, prognosis, and treatment of cancer.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev.med.59.053006.104707