The influence of parathyroid hormone on the adult hematopoietic stem cell niche

Adult hematopoietic stem cells (HSCs) reside in the bone marrow in stable microenvironments known as the stem cell niche. One key component of the stem cell niche is cells of the osteoblastic lineage. Factors that are known to affect osteoblast activity, such as parathyroid hormone (PTH), have also...

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Veröffentlicht in:	Current osteoporosis reports 2009-07, Vol.7 (2), p.53-57
Hauptverfasser:	Rashidi, Narges, Adams, Gregor B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - physiology Epidemiology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - physiology Humans Medicine Medicine & Public Health Models, Animal Orthopedics Osteoblasts - cytology Osteoblasts - physiology Parathyroid Hormone - physiology Signal Transduction - physiology Stem Cell Niche - cytology Stem Cell Niche - physiology Stem Cell Transplantation
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Zusammenfassung:	Adult hematopoietic stem cells (HSCs) reside in the bone marrow in stable microenvironments known as the stem cell niche. One key component of the stem cell niche is cells of the osteoblastic lineage. Factors that are known to affect osteoblast activity, such as parathyroid hormone (PTH), have also been shown to affect the HSCs. Treatment of mice with PTH has led to beneficial effects on the HSC pool, which have led to clinical trials of PTH treatment to enhance HSC-based therapies.
ISSN:	1544-1873 1544-2241
DOI:	10.1007/s11914-009-0010-7