RIP Kinases at the Crossroads of Cell Death and Survival

Protein kinases of the receptor interacting protein (RIP) family collaborate with death receptor proteins to regulate cell death. Recent studies ( Cho et al., 2009; He et al., 2009; Zhang et al., 2009) reveal that the RIP3 kinase functions with RIP1 at the crossroads of apoptosis, necroptosis, and c...

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Veröffentlicht in:	Cell 2009-07, Vol.138 (2), p.229-232
Hauptverfasser:	Declercq, Wim, Vanden Berghe, Tom, Vandenabeele, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Death Cell Survival Humans Mice Nuclear Pore Complex Proteins - metabolism Receptor-Interacting Protein Serine-Threonine Kinases - metabolism RNA-Binding Proteins - metabolism Signal Transduction
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Beschreibung
Zusammenfassung:	Protein kinases of the receptor interacting protein (RIP) family collaborate with death receptor proteins to regulate cell death. Recent studies ( Cho et al., 2009; He et al., 2009; Zhang et al., 2009) reveal that the RIP3 kinase functions with RIP1 at the crossroads of apoptosis, necroptosis, and cell survival.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2009.07.006