A New Therapeutic Target for Leukemia Comes to the Surface

A New Therapeutic Target for Leukemia Comes to the Surface

Expression of the cell-surface protein CD47 allows some normal cells to avoid phagocytosis by macrophages. In this issue, Jaiswal et al. (2009) and Majeti et al. (2009) show that elevated CD47 expression by leukemic stem cells inhibits macrophage activity and is an indicator of poor prognosis for pa...

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Veröffentlicht in:Cell 2009-07, Vol.138 (2), p.226-228
Hauptverfasser: Ritchie, David S., Smyth, Mark J.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
CD47 Antigen - immunology
Humans
Leukemia, Myeloid, Acute - immunology
Leukemia, Myeloid, Acute - therapy
Macrophages - immunology
Mice
Neoplastic Stem Cells - immunology
Phagocytosis
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Zusammenfassung:Expression of the cell-surface protein CD47 allows some normal cells to avoid phagocytosis by macrophages. In this issue, Jaiswal et al. (2009) and Majeti et al. (2009) show that elevated CD47 expression by leukemic stem cells inhibits macrophage activity and is an indicator of poor prognosis for patients with acute myeloid leukemia.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2009.07.005