Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

L- and D-stereoisomers of amicetose were generated by combining sugar biosynthesis genes from four different antibiotic gene clusters and both sugars were transferred to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2005-03 (12), p.1604-1606
Hauptverfasser: Pérez, María, Lombó, Felipe, Zhu, Lili, Gibson, Miranda, Braña, Alfredo F, Rohr, Jurgen, Salas, José A, Méndez, Carmen
Format: Artikel
Sprache:eng
Schlagworte:
Cloning, Molecular
Enzymes - genetics
Hexoses - biosynthesis
Hexoses - genetics
Molecular Structure
Naphthacenes - chemistry
Naphthacenes - classification
Naphthacenes - pharmacology
Plasmids - genetics
Plasmids - metabolism
Stereoisomerism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:L- and D-stereoisomers of amicetose were generated by combining sugar biosynthesis genes from four different antibiotic gene clusters and both sugars were transferred to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase.
ISSN:1359-7345
1364-548X
DOI:10.1039/b417815g