Transient solution to the bioheat equation and optimization for magnetic fluid hyperthermia treatment
Two finite concentric spherical regions were considered as the tissue model for magnetic fluid hyperthermia treatment. The inner sphere represents the diseased tissue containing magnetic particles that generate heat when an alternating magnetic field is applied. The outer sphere represents the healt...
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| Veröffentlicht in: | International journal of hyperthermia 2005-02, Vol.21 (1), p.57-75 |
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| container_title | International journal of hyperthermia |
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| creator | Bagaria, H. G. Johnson, D. T. |
| description | Two finite concentric spherical regions were considered as the tissue model for magnetic fluid hyperthermia treatment. The inner sphere represents the diseased tissue containing magnetic particles that generate heat when an alternating magnetic field is applied. The outer sphere represents the healthy tissue. Blood perfusion effects are included in both the regions. Analytical and numerical solutions of the one-dimensional bioheat transfer equation were obtained with constant and spatially varying heat generation in the inner sphere. The numerical solution was found to be in good agreement with the analytical solution. In an ideal hyperthermia treatment, all the diseased tissues should be selectively heated without affecting any healthy tissue. The present work optimized the magnetic particle concentration in an attempt to achieve the ideal hyperthermia conditions. It was found that, for a fixed amount of magnetic particles, optimizing the magnetic particle distribution in the diseased tissue can significantly enhance the therapeutic temperature levels in the diseased tissue while maintaining the same level of heating in the healthy tissue. |
| doi_str_mv | 10.1080/02656730410001726956 |
| format | Article |
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It was found that, for a fixed amount of magnetic particles, optimizing the magnetic particle distribution in the diseased tissue can significantly enhance the therapeutic temperature levels in the diseased tissue while maintaining the same level of heating in the healthy tissue.</description><identifier>ISSN: 0265-6736</identifier><identifier>EISSN: 1464-5157</identifier><identifier>DOI: 10.1080/02656730410001726956</identifier><identifier>PMID: 15764351</identifier><identifier>CODEN: IJHYEQ</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; bioheat transfer equation ; Biological and medical sciences ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. 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G.</creatorcontrib><creatorcontrib>Johnson, D. T.</creatorcontrib><title>Transient solution to the bioheat equation and optimization for magnetic fluid hyperthermia treatment</title><title>International journal of hyperthermia</title><addtitle>Int J Hyperthermia</addtitle><description>Two finite concentric spherical regions were considered as the tissue model for magnetic fluid hyperthermia treatment. The inner sphere represents the diseased tissue containing magnetic particles that generate heat when an alternating magnetic field is applied. The outer sphere represents the healthy tissue. Blood perfusion effects are included in both the regions. Analytical and numerical solutions of the one-dimensional bioheat transfer equation were obtained with constant and spatially varying heat generation in the inner sphere. The numerical solution was found to be in good agreement with the analytical solution. In an ideal hyperthermia treatment, all the diseased tissues should be selectively heated without affecting any healthy tissue. The present work optimized the magnetic particle concentration in an attempt to achieve the ideal hyperthermia conditions. It was found that, for a fixed amount of magnetic particles, optimizing the magnetic particle distribution in the diseased tissue can significantly enhance the therapeutic temperature levels in the diseased tissue while maintaining the same level of heating in the healthy tissue.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>bioheat transfer equation</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Humans</subject><subject>Hyperthermia</subject><subject>Hyperthermia, Induced - methods</subject><subject>Hyperthermia, Induced - standards</subject><subject>Intensive care medicine</subject><subject>magnetic dispersions</subject><subject>Magnetics</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Neuropharmacology</subject><subject>Neuroprotective agent</subject><subject>Pharmacology. Drug treatments</subject><subject>Reproducibility of Results</subject><subject>separation of variables</subject><subject>Transfusions. Complications. Transfusion reactions. 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Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Humans</topic><topic>Hyperthermia</topic><topic>Hyperthermia, Induced - methods</topic><topic>Hyperthermia, Induced - standards</topic><topic>Intensive care medicine</topic><topic>magnetic dispersions</topic><topic>Magnetics</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Neuropharmacology</topic><topic>Neuroprotective agent</topic><topic>Pharmacology. Drug treatments</topic><topic>Reproducibility of Results</topic><topic>separation of variables</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bagaria, H. G.</creatorcontrib><creatorcontrib>Johnson, D. 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T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transient solution to the bioheat equation and optimization for magnetic fluid hyperthermia treatment</atitle><jtitle>International journal of hyperthermia</jtitle><addtitle>Int J Hyperthermia</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>21</volume><issue>1</issue><spage>57</spage><epage>75</epage><pages>57-75</pages><issn>0265-6736</issn><eissn>1464-5157</eissn><coden>IJHYEQ</coden><abstract>Two finite concentric spherical regions were considered as the tissue model for magnetic fluid hyperthermia treatment. The inner sphere represents the diseased tissue containing magnetic particles that generate heat when an alternating magnetic field is applied. The outer sphere represents the healthy tissue. Blood perfusion effects are included in both the regions. 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| source | MEDLINE; Taylor & Francis:Master (3349 titles) |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy bioheat transfer equation Biological and medical sciences Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Humans Hyperthermia Hyperthermia, Induced - methods Hyperthermia, Induced - standards Intensive care medicine magnetic dispersions Magnetics Medical sciences Models, Biological Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Reproducibility of Results separation of variables Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Transient solution to the bioheat equation and optimization for magnetic fluid hyperthermia treatment |
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