Steroids’ transformations in Penicillium notatum culture

The application of Penicillium notatum genus for biotransformations of steroids has been investigated. The reactions observed include insertion of an oxygen atom into D-ring of steroids, 15α-hydroxylation of 17α-methyl testosterone derivatives, ester bond hydrolysis, and degradation of a testosteron...

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Veröffentlicht in:	Steroids 2005-03, Vol.70 (3), p.193-198
Hauptverfasser:	Bartmańska, Agnieszka, Dmochowska-Gładysz, Jadwiga, Huszcza, Ewa
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstenedione - chemistry Biological and medical sciences Biotransformation Cell Culture Techniques - methods Chromatography, Thin Layer Circular Dichroism Esters Ethisterone - urine Fundamental and applied biological sciences. Psychology Hydrolysis Magnetic Resonance Spectroscopy Methandrostenolone - chemistry Methyltestosterone - chemistry Models, Chemical Nandrolone - chemistry Oxygen - metabolism Penicillium - metabolism Penicillium notatum Progesterone - chemistry Spectrophotometry Spectrophotometry, Infrared Steroids Testolactone Testosterone - analogs & derivatives Testosterone - chemistry Testosterone - metabolism Testosterone Propionate - chemistry Vertebrates: endocrinology
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Beschreibung
Zusammenfassung:	The application of Penicillium notatum genus for biotransformations of steroids has been investigated. The reactions observed include insertion of an oxygen atom into D-ring of steroids, 15α-hydroxylation of 17α-methyl testosterone derivatives, ester bond hydrolysis, and degradation of a testosterone derivatives side chain. Microbial production of testolactones, the biologically active compounds, was also achieved using this strain in up to 98% yield.
ISSN:	0039-128X 1878-5867
DOI:	10.1016/j.steroids.2004.11.011