Growth of Staphylococcus aureus with Defective Siderophore Production in Human Peritoneal Dialysate Solution

In this study, we attempted to determine the effects of iron-availability and the activity of the bacterial iron-uptake system (IUS) on the growth of Staphylococcus aureus in human peritoneal dialysate (HPD) solution. A streptonigrin-resistant S. aureus (SRSA) strain, isolated from S. aureus ATCC 6538, exhibited defective siderophore production, thereby resulting in ineffective uptake of iron from low iron-saturated transferrin. The growth of both strains was stimulated in HPD solution supplemented with FeCl₃ and holotransferrin, but growth was inhibited in HPD solution which had been supplemented with apotransferrin and dipyridyl.