Microwave-Promoted Suzuki Reactions of Aryl Chlorides in Aqueous Media

The microwave-promoted Suzuki coupling reaction of aryl chlorides with boronic acids performed in an aqueous media was studied using the air- and moisture-stable catalyst POPd2 (dihydrogen di-μ-chlorodichlorobis(di-tert-butylphosphinito-κP)dipalladate (2−)). This catalyst system under microwave cond...

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Veröffentlicht in:	Journal of organic chemistry 2005-03, Vol.70 (6), p.2332-2334
Hauptverfasser:	Miao, Guobin, Ye, Ping, Yu, Libing, Baldino, Carmen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biphenyl Compounds - chemical synthesis Boronic Acids - chemistry Catalysis Catalysts: preparations and properties Chemistry Exact sciences and technology General and physical chemistry Hydrocarbons, Chlorinated - chemistry Microwaves Molecular Structure Noncondensed benzenic compounds Organic chemistry Organometallic Compounds - chemistry Platinum - chemistry Preparations and properties Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry Water - chemistry
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Beschreibung
Zusammenfassung:	The microwave-promoted Suzuki coupling reaction of aryl chlorides with boronic acids performed in an aqueous media was studied using the air- and moisture-stable catalyst POPd2 (dihydrogen di-μ-chlorodichlorobis(di-tert-butylphosphinito-κP)dipalladate (2−)). This catalyst system under microwave conditions (150 °C, 15 min) provided coupled products with yields ranging from 64% to 99%. This method tolerated a variety of substituents and sterically hindered substrates.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo047975c