Adenovirus-based genetic vaccines for biodefense

The robust host responses elicited against transgenes encoded by (E1-)(E3-) adenovirus (Ad) gene transfer vectors can be used to develop Ad-based vectors as platform technologies for vaccines against potential bioterror pathogens. This review focuses on pathogens of major concern as bioterror agents...

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Veröffentlicht in:	Human gene therapy 2005-02, Vol.16 (2), p.157-168
Hauptverfasser:	BOYER, Julie L, KOBINGER, Gary, WILSON, James M, CRYSTAL, Ronald G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus AIDS Vaccines Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Bioterrorism Communicable Disease Control Fundamental and applied biological sciences. Psychology Gene therapy Genetic Therapy Genetic Vectors Health. Pharmaceutical industry HIV Infections - genetics HIV Infections - therapy HIV-1 - genetics Humans Industrial applications and implications. Economical aspects Medical sciences Transfusions. Complications. Transfusion reactions. Cell and gene therapy Viral Proteins - genetics Viral Proteins - immunology
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Beschreibung
Zusammenfassung:	The robust host responses elicited against transgenes encoded by (E1-)(E3-) adenovirus (Ad) gene transfer vectors can be used to develop Ad-based vectors as platform technologies for vaccines against potential bioterror pathogens. This review focuses on pathogens of major concern as bioterror agents and why Ad vectors are ideal as anti-bioterror vaccine platforms, providing examples from our laboratories of using Ad vectors as vaccines against potential bioterror pathogens and how Ad vectors can be developed to enhance vaccine efficacy in the bioterror war.
ISSN:	1043-0342 1557-7422
DOI:	10.1089/hum.2005.16.157