Clinical review : The antitumoral effects of somatostatin analog therapy in acromegaly

Somatostatin analogs are the mainstay of medical therapy for acromegaly. Suppression of GH hypersecretion, lowering of IGF-I production, and control of symptoms are established benefits of therapy. In addition, clinically significant tumor shrinkage has been seen in a number of studies, particularly...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2005-03, Vol.90 (3), p.1856-1863
1. Verfasser:	BEVAN, John S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acromegaly - drug therapy Acromegaly - pathology Biological and medical sciences Endocrinopathies Fundamental and applied biological sciences. Psychology Humans Hypothalamus. Hypophysis. Epiphysis (diseases) Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Pituitary Neoplasms - drug therapy Pituitary Neoplasms - pathology Somatostatin - analogs & derivatives Vertebrates: endocrinology
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Beschreibung
Zusammenfassung:	Somatostatin analogs are the mainstay of medical therapy for acromegaly. Suppression of GH hypersecretion, lowering of IGF-I production, and control of symptoms are established benefits of therapy. In addition, clinically significant tumor shrinkage has been seen in a number of studies, particularly in patients undergoing primary medical therapy. This review summarizes current knowledge of the effects of somatostatin analogs on tumor size and cellular morphology and examines the available data on predictors of tumor shrinkage.
ISSN:	0021-972X 1945-7197
DOI:	10.1210/jc.2004-1093