Hyperadrenocorticism in a dog due to ectopic secretion of adrenocorticotropic hormone

Spontaneous hyperadrenocorticism in dogs is known to be the result of excessive secretion of adrenocorticotropic hormone (ACTH) by the pituitary gland or excessive autonomous glucocorticoid secretion by an adrenocortical tumor. Here, we report on an 8-year-old German shepherd dog in which ACTH-depen...

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Veröffentlicht in:	Domestic animal endocrinology 2005-04, Vol.28 (3), p.338-348
Hauptverfasser:	Galac, S., Kooistra, H.S., Voorhout, G., van den Ingh, T.S.G.A.M., Mol, J.A., van den Berg, G., Meij, B.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Neoplasms - secretion Abdominal Neoplasms - veterinary ACTH ACTH Syndrome, Ectopic - complications ACTH Syndrome, Ectopic - diagnosis ACTH Syndrome, Ectopic - veterinary adrenal cortex Adrenocortical Hyperfunction - etiology Adrenocortical Hyperfunction - veterinary adrenocortical hyperplasia Adrenocorticotropic Hormone - blood Adrenocorticotropic Hormone - secretion Animals antineoplastic agents Canine corticotropin corticotropin-releasing hormone Corticotropin-Releasing Hormone - pharmacology Cortisol Cushing syndrome Cushing's syndrome dexamethasone disease diagnosis Dog Diseases - diagnosis Dog Diseases - etiology Dog Diseases - surgery Dogs drug therapy hormone secretion Hydrocortisone - blood hyperadrenocorticism Liver - diagnostic imaging Male neoplasms Neuroendocrine tumor Neuroendocrine Tumors - secretion Neuroendocrine Tumors - veterinary Tomography, X-Ray Computed - veterinary trilostane Ultrasonography - veterinary urinary corticoid/creatinine ratio
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Zusammenfassung:	Spontaneous hyperadrenocorticism in dogs is known to be the result of excessive secretion of adrenocorticotropic hormone (ACTH) by the pituitary gland or excessive autonomous glucocorticoid secretion by an adrenocortical tumor. Here, we report on an 8-year-old German shepherd dog in which ACTH-dependent hyperadrenocorticism was a result of ectopic ACTH secretion and could be related to an abdominal neuroendocrine tumor. Hyperadrenocorticism was diagnosed on the basis of the history, clinical signs, and elevated urinary corticoid/creatinine ratios (UCCRs; 236 and 350 × 10 −6; reference range
ISSN:	0739-7240 1879-0054
DOI:	10.1016/j.domaniend.2004.11.001