Classification analysis of the transcriptosome of nonlesional cultured dermal fibroblasts from systemic sclerosis patients with early disease

Classification analysis of the transcriptosome of nonlesional cultured dermal fibroblasts from systemic sclerosis patients with early disease

Objective To compare the transcriptosome of early‐passage nonlesional dermal fibroblasts from systemic sclerosis (SSc) patients with diffuse disease and matched normal controls in order to gain further understanding of the gene activation patterns that occur in early disease. Methods Total RNA was i...

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Veröffentlicht in:Arthritis and rheumatism 2005-03, Vol.52 (3), p.865-876
Hauptverfasser: Tan, Filemon K., Hildebrand, Bernard August, Lester, Malisa S., Stivers, David N., Pounds, Stanley, Zhou, Xiaodong, Wallis, Debra D., Milewicz, Dianna M., Reveille, John D., Mayes, Maureen D., Jin, Li, Arnett, Frank C.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Dermis
Fibroblasts - physiology
Gene Expression Regulation - genetics
Humans
Medical sciences
Oligonucleotide Array Sequence Analysis
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Scleroderma, Systemic - genetics
Transcriptional Activation - genetics
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Zusammenfassung:Objective To compare the transcriptosome of early‐passage nonlesional dermal fibroblasts from systemic sclerosis (SSc) patients with diffuse disease and matched normal controls in order to gain further understanding of the gene activation patterns that occur in early disease. Methods Total RNA was isolated from early‐passage fibroblasts obtained from nonlesional skin biopsy specimens from 21 patients with diffuse SSc (disease duration
ISSN:0004-3591
1529-0131
DOI:10.1002/art.20871