Very Fast Product Release and Catalytic Turnover of DNA Photolyase

Repair champion: The substrate binding and product release of the light‐driven DNA repair enzyme photolyase were followed by a novel fluorescence approach. Unexpectedly, release of repaired nucleobases from the substrate binding pocket appears to be as fast as 50 μs. Moreover, catalytic turnover und...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2009-07, Vol.10 (11), p.1777-1780
Hauptverfasser:	Espagne, Agathe, Byrdin, Martin, Eker, Andre P.M, Brettel, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Deoxyribodipyrimidine Photo-Lyase - metabolism DNA Damage enzyme catalysis Flavin-Adenine Dinucleotide - analogs & derivatives Flavin-Adenine Dinucleotide - chemistry flavoproteins Fluorescence fluorescence spectroscopy Kinetics Pyrimidine Dimers - chemistry Spectrometry, Fluorescence time-resolved spectroscopy
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