Clinical significance of the detection of Candida albicans germ tube-specific antibodies in critically ill patients
The present study, comprising a prospective multicentre study including 53 non-neutropenic patients from intensive care units (ICU) in six Spanish tertiary-care hospitals, was carried out to determine the clinical significance and influence on mortality of Candida albicans germ tube-specific antibod...
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Veröffentlicht in: | Clinical microbiology and infection 2009-06, Vol.15 (6), p.592-595 |
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Sprache: | eng |
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Zusammenfassung: | The present study, comprising a prospective multicentre study including 53 non-neutropenic patients from intensive care units (ICU) in six Spanish tertiary-care hospitals, was carried out to determine the clinical significance and influence on mortality of Candida albicans germ tube-specific antibodies (CAGTA). There were 22 patients (41.5%) for whom the CAGTA results were positive, although none of had a blood culture positive for Candida. The intra-ICU mortality rate was significantly lower (p = 0.004) in CAGTA-positive patients (61.2% vs. 22.7%). Multivariate analysis confirmed that a positive CAGTA result was the only protective factor to be independently associated with ICU mortality (β coefficient = −0.3856; 95% confidence interval = −0.648 to −0.123). |
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ISSN: | 1198-743X 1469-0691 |
DOI: | 10.1111/j.1469-0691.2009.02794.x |