Target-Family-Oriented Focused Libraries for Kinases--Conceptual Design Aspects and Commercial Availability
Tailor‐made libraries may increase the likelihood of identifying potential lead candidates in early drug‐discovery phases. That at least 12 commercial vendors offer their services in providing compound collections of tentative kinase inhibitors reflects the growing interest in kinases within the pha...
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| Veröffentlicht in: | Chembiochem : a European journal of chemical biology 2005-03, Vol.6 (3), p.500-505 |
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| container_issue | 3 |
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| container_title | Chembiochem : a European journal of chemical biology |
| container_volume | 6 |
| creator | Prien, Olaf |
| description | Tailor‐made libraries may increase the likelihood of identifying potential lead candidates in early drug‐discovery phases. That at least 12 commercial vendors offer their services in providing compound collections of tentative kinase inhibitors reflects the growing interest in kinases within the pharmaceutical industry. Some conceptual design approaches for focused library design for the kinase family are reviewed, and the design concepts of these commercialized libraries is discussed. |
| doi_str_mv | 10.1002/cbic.200400117 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1439-4227 |
| ispartof | Chembiochem : a European journal of chemical biology, 2005-03, Vol.6 (3), p.500-505 |
| issn | 1439-4227 1439-7633 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Drug Design Drug Evaluation, Preclinical - instrumentation focused library inhibitors kinases Ligands molecular modeling Phosphotransferases - chemistry Phosphotransferases - classification Phosphotransferases - metabolism Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology |
| title | Target-Family-Oriented Focused Libraries for Kinases--Conceptual Design Aspects and Commercial Availability |
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