Target-Family-Oriented Focused Libraries for Kinases--Conceptual Design Aspects and Commercial Availability

Tailor‐made libraries may increase the likelihood of identifying potential lead candidates in early drug‐discovery phases. That at least 12 commercial vendors offer their services in providing compound collections of tentative kinase inhibitors reflects the growing interest in kinases within the pharmaceutical industry. Some conceptual design approaches for focused library design for the kinase family are reviewed, and the design concepts of these commercialized libraries is discussed.