The Dynamics of Histone H1 Function in Chromatin

The Dynamics of Histone H1 Function in Chromatin

Over 80% of the nucleosomes in chromatin contain histone H1, a protein family known to affect the structure and activity of chromatin. Genetic studies and in vivo imaging experiments are changing the traditional view of H1 function and mechanism of action. H1 variants are partially redundant, mobile...

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Veröffentlicht in:Molecular cell 2005-03, Vol.17 (5), p.617-620
Hauptverfasser: Bustin, Michael, Catez, Frédéric, Lim, Jae-Hwan
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chromatin - chemistry
Chromatin - physiology
DNA - chemistry
DNA Replication
Histones - chemistry
Histones - genetics
Histones - physiology
Humans
Models, Biological
Nucleosomes - metabolism
Phenotype
Plant Proteins - chemistry
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Beschreibung
Zusammenfassung:Over 80% of the nucleosomes in chromatin contain histone H1, a protein family known to affect the structure and activity of chromatin. Genetic studies and in vivo imaging experiments are changing the traditional view of H1 function and mechanism of action. H1 variants are partially redundant, mobile molecules that interact with nucleosomes as members of a dynamic protein network and serve as fine tuners of chromatin function.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2005.02.019